ArticleInternational journal of molecular sciences2026
CRISPR-Cpf1-Mediated Gene-Editing System Based on a Single Bidirectional Promoter.
Soomin Kim, Gyeong-Nam Kim, Yeon-Ju Jeong, Jeongin Cho, Mingyo Jang, Jinpyo Hong, Young Hoon Sung
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
7 authors.
Soomin KimDepartment of Medical Science, Asan Medical Institute of Convergence Science and Technology, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea.
Gyeong-Nam KimDepartment of Medical Science, Asan Medical Institute of Convergence Science and Technology, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea.
Yeon-Ju JeongDepartment of Medical Science, Asan Medical Institute of Convergence Science and Technology, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea.
Jeongin ChoDepartment of Medical Science, Asan Medical Institute of Convergence Science and Technology, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea.
Mingyo JangDepartment of Medical Science, Asan Medical Institute of Convergence Science and Technology, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea.
Jinpyo HongDepartment of Convergence Medicine, Convergence Medicine Research Center, Biomedical Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Republic of Korea.ORCID 0000-0002-4776-4396 Young Hoon SungDepartment of Convergence Medicine, Convergence Medicine Research Center, Biomedical Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Republic of Korea.ORCID 0000-0002-1508-9883 Funding
Korea Drug Development Fund RS-2023-00283544Ministry of Science and ICT 2018R1A2B6002192Ministry of Trade, Industry and Energy 20012477
6 · The paper itselfAbstract
Recent advances in gene therapy have highlighted the potential of CRISPR-based gene-editing systems combined with adeno-associated virus (AAV) vectors. However, the limited packaging capacity of AAV remains a significant challenge for the simultaneous expression of Cas effector proteins and guide RNAs within a single vector. To address this limitation, we developed a compact AAV vector that enables the co-expression of
Indexed as
Bacterial ProteinsClustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Associated ProteinsCRISPR-Cas SystemsEndodeoxyribonucleasesGene EditingPromoter Regions, GeneticAcidaminococcusAnimalsDependovirusEndonucleasesGenetic VectorsHEK293 CellsHumansMiceRNA, Guide, CRISPR-Cas SystemsBacterial ProteinsCas12a proteinCRISPR-Associated ProteinsEndodeoxyribonucleasesEndonucleasesRNA, Guide, CRISPR-Cas SystemsAAV deliverybidirectional H1 promoterCRISPR–AsCpf1genome editing
Identifiers
PMID42196146
PMCPMC13206784
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