Mechanisms of Ibuprofen Retention and Release in Dual-Responsive P(NIPAM-co-AAc) Nanogels: Coupling of Mesh Sieving and Affinity Switching.

Yiqi Zhou, Haodong Yao, Bicheng Han, Jihong Sun, Huijie Ge, Shiyang Bai, Lina Zhao

Abstract read

In one paragraph

Article in Gels (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Yiqi ZhouBeijing Key Laboratory for Green Catalysis and Separation, Institute of Matter Science, Beijing University of Technology, Beijing 100124, China.

Haodong YaoMulti-Disciplinary Research Division, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.ORCID 0000-0001-5959-8594

Bicheng HanState Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.

Jihong SunBeijing Key Laboratory for Green Catalysis and Separation, Institute of Matter Science, Beijing University of Technology, Beijing 100124, China.ORCID 0000-0001-6106-0806

Huijie GeBeijing Key Laboratory for Green Catalysis and Separation, Institute of Matter Science, Beijing University of Technology, Beijing 100124, China.

Shiyang BaiBeijing Key Laboratory for Green Catalysis and Separation, Institute of Matter Science, Beijing University of Technology, Beijing 100124, China.ORCID 0000-0003-4694-9062

Lina ZhaoMulti-Disciplinary Research Division, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.

Funding

Directional Institutionalized Scientific Research Platform of the Beijing Synchrotron Radiation Facility, Chinese Academy of Sciences JZHKYPT-2021-02Innovation Program for IHEP E35457U210National Key Research and Development Program of China 2021YFA1200904National Natural Science Foundation of China 12375326Strategic Priority Research Program of the Chinese Academy of Sciences XDA0480600Strategic Priority Research Program of the Chinese Academy of Sciences XDA0530301

6 · The paper itself

Abstract

Rational design of smart nanogels for drug delivery requires molecular-level understanding of how structural evolution and drug-carrier interactions couple under multiple stimuli. Here, pH/temperature dual-responsive P(NIPAM-co-AAc) nanogels containing 0-20 mol% AAc were investigated by combining all-atom molecular dynamics simulations with in vitro ibuprofen (IBU) release experiments under acidic (pH 2.75) and weakly basic (pH 7.4) conditions at 298 and 310 K. The simulations identified CA-5-L-298 as the most retained system, with the lowest IBU diffusion coefficient (0.92 × 10

Indexed as

hydrogen bondmesh sizemolecular dynamics simulationmulti-stimuli-responsive drug deliveryP(NIPAM-co-AAc) nanogels

Identifiers

PMID42196065

DOI10.3390/gels12050379

PMCPMC13205422

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.