ArticleMaterials (Basel, Switzerland)2026
Design and Characterization of 3D Printed Auxetic PLA-HA Composite Scaffolds for Biomedical Application.
Article in Materials (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Additive manufacturing (AM) techniques are becoming key factors for repairing and replacing damaged bone. These techniques enable the customization of implants, which can be tailored to the specific area to be treated or healed. Additionally, the combination of absorbable and osteoconductive biomaterials with 3D printing could eliminate second surgeries to remove implants, which is particularly relevant in pediatric and geriatric patients. The capabilities of AM in this context affect not only the external shape but also the internal microarchitecture, where the arrangement of struts to develop complex infills enhances relevant properties such as specific strength, degradation rate, and vascularization. In this study, auxetic scaffold structures made of both polylactic acid (PLA) and a PLA-hydroxyapatite (PLA-HA) composite with 40 wt% of hydroxyapatite (HA) are designed and produced using Fused Filament Fabrication (FFF). Samples of PLA and PLA-HA were 3D printed in dense samples and with auxetic infills. In dense samples, the characterization is performed by X-ray diffraction (XRD), Raman spectroscopy, wettability tests, nanoindentation, and tribological assessments. Two auxetic cellular models have been tested after degradation in PBS media, and their microstructural, structural, and mechanical properties are analyzed. Results show that the addition of hydroxyapatite (HA) significantly improves the hydrophilicity of the PLA matrix, as evidenced by a decrease in water contact angle from 73.4 ± 4.4° to 52.6 ± 2.8° (≈28% reduction), while also enhancing its mechanical and tribological properties, with hardness increasing from 207 ± 30 MPa to 241 ± 28 MPa (≈15%) and Young's modulus from 4.08 ± 0.55 GPa to 6.24 ± 0.61 GPa (≈53%). Additionally, biodegradation of PLA-HA composites reveals a significant reduction in mechanical properties after 15 days, while the auxetic re-entrant structures mostly retain their shape during compression testing.
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