ArticleLife (Basel, Switzerland)2026
Muscle Function Impairment in Crohn's Disease Patients: Risk Factors and Clinical Implications-Single-Tertiary-Center Experience.
Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Sarcopenia in inflammatory bowel disease can significantly influence disease course. Since current assessment focuses mainly on muscle quantity, we aimed to evaluate muscle function in Crohn's disease (CD) patients and identify those at increased risk of muscle function impairment. This cross-sectional study included 84 patients with CD (76.2% male, mean age 35 ± 11 years) receiving infliximab. Body composition was assessed by bioelectrical impedance analysis, muscle strength by handgrip strength (HGS), and physical performance by gait speed. Half of the cohort demonstrated reduced muscle strength relative to age- and sex-adjusted norms, while none met criteria for confirmed sarcopenia. One third of the patients had low physical performance and only one patient screened positive for sarcopenia. In multivariable linear regression, sex was the strongest independent predictor of HGS (
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