Evidence map›Paper›PMID 42195281›Full record

ArticleLife (Basel, Switzerland)2026

5-ALA/SFC Mitigates Tau Toxicity via Lowering Oxidative Stress in a

Arisa Tamura, Marie Noguchi, Naoko Nozawa, Emiko Suzuki, Kanae Ando

Abstract read
In one paragraph

Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Arisa TamuraDepartment of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Hachioji, Tokyo 192-0397, Japan.
Marie NoguchiDepartment of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Hachioji, Tokyo 192-0397, Japan.
Naoko NozawaDivision of Pharmaceutical Research, SBI Pharmaceuticals Co., Ltd., Tokyo 106-6020, Japan.
Emiko SuzukiDepartment of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Hachioji, Tokyo 192-0397, Japan.ORCID 0000-0002-4005-0542
Kanae AndoDepartment of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Hachioji, Tokyo 192-0397, Japan.ORCID 0000-0002-3956-276X

Funding

Japan Agency for Medical Research and Development JP24wm0625509Japan Agency for Medical Research and Development JP25wm0625509Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research (B) 24K02860Tokyo Metropolitan University MIYAKO-MIRAI Project
6 · The paper itself

Abstract

Mitochondrial dysfunctions contribute to the pathogenesis of tauopathies, a group of neurodegenerative diseases with abnormal accumulation of microtubule-associated protein tau. The combination of 5-aminolevulinic acid (5-ALA) and sodium ferrous citrate (SFC) is known to improve mitochondrial functions. Here, we report that 5-ALA combined with SFC (5-ALA/SFC) improves mitochondrial functions and mitigates neurodegeneration in transgenic

Indexed as

5-ALA/SFCDrosophila model of tau toxicitymitochondrianeurodegenerationoxidative stress

Identifiers

PMID42195281
PMCPMC13208956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.