USP13 Downregulation Distinguishes Malignant from Adjacent Non-Neoplastic Prostate Tissue and Suggests Altered PTEN-Related Regulatory Pathways in a Korean Cohort.

Jae Heon Kim, Miho Song, Kwang Woo Lee, Suyeon Park, Eunkyung Han, Ahrim Moon, Yun Seob Song

Abstract read

In one paragraph

Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Jae Heon KimDepartment of Urology, School of Medicine, Soonchunhyang University, Seoul 04401, Republic of Korea.ORCID 0000-0002-4490-3610

Miho SongDepartment of Urology, School of Medicine, Soonchunhyang University, Seoul 04401, Republic of Korea.ORCID 0009-0003-8345-6686

Kwang Woo LeeDepartment of Urology, School of Medicine, Soonchunhyang University, Bucheon 14584, Republic of Korea.ORCID 0000-0002-8882-2492

Suyeon ParkAcademic Research Office, Department of Biostatistics, Soonchunhyang University Seoul Hospital, Seoul 04401, Republic of Korea.ORCID 0000-0002-6391-557X

Eunkyung HanDepartment of Pathology, School of Medicine, Soonchunhyang University, Bucheon 14584, Republic of Korea.ORCID 0000-0003-1697-3336

Ahrim MoonDepartment of Pathology, School of Medicine, Soonchunhyang University, Bucheon 14584, Republic of Korea.

Yun Seob SongDepartment of Urology, School of Medicine, Soonchunhyang University, Seoul 04401, Republic of Korea.

Funding

National Research Foundation of Korea RS-2024-00333544

6 · The paper itself

Abstract

Ubiquitin-specific protease 13 (USP13) is a deubiquitinating enzyme that stabilizes phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a well-established tumor suppressor involved in PI3K/AKT signaling. This study aimed to evaluate the relationship between USP13 immunohistochemical staining intensity and clinicopathological factors associated with prostate cancer progression. USP13 staining was scored as grade 0 (negative), 1 (weak), 2 (moderate), or 3 (strong) in 242 prostate cancer tissues and 22 adjacent non-neoplastic control tissues. Higher USP13 grades were exhibited by adjacent non-neoplastic tissues than prostate carcinoma. In comparison, lower USP13 grades were observed in 88.6% of the neoplastic regions (

Indexed as

deubiquitinasesprostate cancerubiquitin-specific protease 13

Identifiers

PMID42195268

DOI10.3390/life16050712

PMCPMC13208592

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