ArticleMedicina (Kaunas, Lithuania)2026
Integrating Genetic Variants and Expression Profiles of Pharmacogenes to Investigate Resistance to Antidepressant Treatment.
Claudia Pisanu, Alessio Squassina, Júlia Perera-Bel, Rosana Carvalho Silva, Lisa Buson, Anna Martinez Sires, Marco Bortolomasi, Valentina Menesello, Giulia Perusi, Bernardo Carpiniello and 10 more
Abstract read
In one paragraphArticle in Medicina (Kaunas, Lithuania), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from itWhat it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
20 authors.
Claudia PisanuSection of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, 09042 Monserrato, Italy.ORCID 0000-0002-9151-4319 Alessio SquassinaSection of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, 09042 Monserrato, Italy.
Rosana Carvalho SilvaDepartment of Molecular and Translational Medicine, University of Brescia, 25121 Brescia, Italy.
Lisa BusonGenetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.ORCID 0000-0003-1910-4232 Anna Martinez SiresHospital del Mar Medical Research Institute (HMRIB), 08003 Barcelona, Spain.
Marco BortolomasiPsychiatric Hospital "Villa Santa Chiara", 37142 Verona, Italy.
Valentina MeneselloDepartment of Molecular and Translational Medicine, University of Brescia, 25121 Brescia, Italy.ORCID 0000-0002-8414-2203 Giulia PerusiDepartment of Molecular and Translational Medicine, University of Brescia, 25121 Brescia, Italy.
Bernardo CarpinielloSection of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09124 Cagliari, Italy.
Ewa Ferensztajn-RochowiakDepartment of Adult Psychiatry, Poznan University of Medical Sciences, 61-701 Poznan, Poland.
Filip RybakowskiDepartment of Adult Psychiatry, Poznan University of Medical Sciences, 61-701 Poznan, Poland.ORCID 0000-0001-5503-3019 Mirko ManchiaSection of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09124 Cagliari, Italy.ORCID 0000-0003-4175-6413 Marie Claude PotierParis Brain Institute (ICM), National Centre for Scientific Research (CNRS), 75794 Paris, France.ORCID 0000-0003-2462-7150 Mara DierssenCentre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology (BIST), 08036 Barcelona, Spain.ORCID 0000-0003-0853-6865 Prompt Study Group
Bernhard T BauneDepartment of Psychiatry, University of Münster, 48149 Münster, Germany.
Massimo GennarelliDepartment of Molecular and Translational Medicine, University of Brescia, 25121 Brescia, Italy.
Alessandra MinelliDepartment of Molecular and Translational Medicine, University of Brescia, 25121 Brescia, Italy.ORCID 0000-0002-9463-7808 Funding
Agence Nationale de la Recherche ANR-20-PERM-0003European Union 101,057,454Federal Ministry of Health 2521FSB004_PROMPTFondation de l'Avenir ANR-10-AIHU-06Generalitat de Catalunya SLD044/20/000001Instituto de Salud Carlos III IHMC22/00026Ministero della Salute ERP-2020-23671059Ministero della Salute RC-2026National Centre for Research and Development PerMed/III/2/PROMPT/2021
6 · The paper itselfAbstract
PubMed holds no abstract for this paper.
Indexed as
Antidepressive AgentsDepressive Disorder, Treatment-ResistantGenetic VariationMajor Depressive DisorderAdultCohort StudiesCytochrome P-450 CYP2B6Cytochrome P-450 CYP2C19Cytochrome P-450 CYP2D6FemaleHumansMaleMicroRNAsMiddle AgedPharmacogeneticsAntidepressive AgentsCYP2B6 protein, humanCYP2C19 protein, humanCytochrome P-450 CYP2B6Cytochrome P-450 CYP2C19Cytochrome P-450 CYP2D6MicroRNAsantidepressantsCYP2C19CYP2D6miRNAmRNApharmacogeneticsprecision psychiatrytreatment-resistant depression
Identifiers
PMID42195218
PMCPMC13209118
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