Mouse Model of Graves' Orbitopathy in Current Research and Future Perspectives.

Gyeong Min Lee, Wook Hyun Jung, Yeseul Kim, Myung In Oh, Sun Young Jang

Abstract readReview

In one paragraph

Review in Medicina (Kaunas, Lithuania), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gyeong Min LeeDepartment of Ophthalmology, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, 1, Singil-ro, Yeongdeungpo-gu, Seoul 07441, Republic of Korea.

Wook Hyun JungDepartment of Ophthalmology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, 170, Jomaru-ro, Bucheon 14584, Republic of Korea.ORCID 0009-0007-4723-054X

Yeseul KimDepartment of Ophthalmology, Yonsei Eagle Eye Center, 39, Daewangpangyo-ro 606beon-gil, Bundang-gu, Seongnam 13524, Republic of Korea.

Myung In OhDepartment of Medicine, Soonchunhyang University College of Medicine, 22, Soonchunhyang-ro, Sinchang-myeon, Asan 31538, Republic of Korea.

Sun Young JangDepartment of Ophthalmology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, 170, Jomaru-ro, Bucheon 14584, Republic of Korea.ORCID 0000-0002-4723-3712

Funding

National Research Foundation of Korea RS-2022-NR075626Soonchunhyang University No. 2026-0025

6 · The paper itself

Abstract

Graves' orbitopathy (GO) is a representative extrathyroidal manifestation of autoimmune thyroid disease. Despite extensive research, the precise pathogenic mechanisms remain incompletely understood. Moreover, the lack of an ideal animal model has limited in vivo investigation, with most studies relying on in vitro systems using orbital fibroblasts. In this review, we discuss currently available mouse models of GO and recent advances in experimental modeling strategies, aiming to provide an integrated framework for future research.

Indexed as

Disease Models, AnimalGraves OphthalmopathyMiceReceptors, ThyrotropinAnimalsAutoantibodiesFibroblastsGenetic VectorsMice, TransgenicOrbitAutoantibodiesReceptors, ThyrotropinTSHR protein, humananimaldisease modelsGraves’ diseaseGraves’ orbitopathymice

Identifiers

PMID42195214

DOI10.3390/medicina62050961

PMCPMC13209123

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.