Evidence map›Paper›PMID 42195093›Full record

ReviewMedicina (Kaunas, Lithuania)2026

Rehabilitation in Adults with Complex Psychosis: A Clinician-Oriented Narrative Review of Multidimensional Approaches to Functional Recovery.

Mario Pinzi, Andrea Fagiolini, Giacomo Gualtieri, Maria Beatrice Rescalli, Caterina Pierini, Alessia Santangelo, Benjamin Patrizio, Alessandro Cuomo

Abstract readReview
In one paragraph

Review in Medicina (Kaunas, Lithuania), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mario PinziDepartment of Molecular Medicine, School of Medicine, University of Siena, 53100 Siena, Italy.ORCID 0009-0003-4229-8714
Andrea FagioliniDepartment of Molecular Medicine, School of Medicine, University of Siena, 53100 Siena, Italy.ORCID 0000-0001-5827-0853
Giacomo GualtieriDepartment of Molecular Medicine, School of Medicine, University of Siena, 53100 Siena, Italy.ORCID 0009-0004-1008-9915
Maria Beatrice RescalliDepartment of Molecular Medicine, School of Medicine, University of Siena, 53100 Siena, Italy.ORCID 0009-0008-8653-9504
Caterina PieriniDepartment of Molecular Medicine, School of Medicine, University of Siena, 53100 Siena, Italy.ORCID 0009-0008-9643-719X
Alessia SantangeloDepartment of Molecular Medicine, School of Medicine, University of Siena, 53100 Siena, Italy.
Benjamin PatrizioDepartment of Molecular Medicine, School of Medicine, University of Siena, 53100 Siena, Italy.
Alessandro CuomoDepartment of Molecular Medicine, School of Medicine, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-9211-5248

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Complex psychosis is a clinically relevant rehabilitation construct rather than a formal diagnostic category and refers to psychotic illness associated with treatment-resistant symptoms, functional impairment, and additional cognitive, psychiatric, neurodevelopmental, or physical health complexity. In this clinician-oriented narrative review, we synthesised current evidence on rehabilitation interventions for adults with complex psychosis, integrating direct evidence from specialist rehabilitation settings with indirect evidence from schizophrenia-spectrum studies when clinically informative. We searched major clinical databases, prioritised guidelines, systematic reviews, meta-analyses, and controlled studies, and organised the synthesis by functional domain and pathway relevance. Evidence was strongest for cognitive remediation, particularly when combined with broader psychiatric rehabilitation or vocational support, for family interventions in relapse prevention, and for individual placement and support in competitive employment. Social-cognitive and metacognitive interventions appear clinically valuable, although transfer to real-world functioning is more variable. Community-based rehabilitation, supported accommodation, illness self-management, and ecological adaptation strategies remain central to functional recovery when embedded within multidisciplinary pathways. Digital and virtual interventions are promising adjuncts, but their efficacy remains heterogeneous and implementation challenges include engagement, privacy, and service integration. Overall, rehabilitation in complex psychosis is most convincing when it is personalised, measurement-based, and delivered through integrated service models linking assessment, intervention selection, supported living, and recovery-oriented care.

Indexed as

Psychiatric RehabilitationPsychotic DisordersRecovery of FunctionAdultHumansSchizophreniacognitive remediationcommunity-based rehabilitationcomplex psychosisfunctional recoveryintegrated caremetacognitionpsychiatric rehabilitationschizophrenia spectrum disorderssocial cognitionsupported employment

Identifiers

PMID42195093
PMCPMC13208723

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.