Evidence map›Paper›PMID 42195016›Full record

ArticleGenes2026

Ebru Dolu, Savaş Orhan, Celal Bulgay, Hasan Hüseyin Kazan, David Varillas-Delgado, Attila Szabo, Mehmet Ali Ergün, Luca Paolo Ardigò

Abstract read
In one paragraph

Article in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ebru DoluInstitute of Health Sciences, Bingöl University, Bingöl 12000, Türkiye.
Savaş OrhanInstitute of Health Sciences, Bingöl University, Bingöl 12000, Türkiye.
Celal BulgaySports Science Faculty, Bingöl University, Bingöl 12000, Türkiye.ORCID 0000-0003-4026-9883
Hasan Hüseyin KazanDepartment of Medical Biology, Gulhane Faculty of Medicine, University of Health Sciences, Ankara 06010, Türkiye.ORCID 0000-0001-7936-8606
David Varillas-DelgadoExercise and Sport Science, Faculty of Health Sciences, Universidad Francisco de Vitoria, 28223 Pozuelo, Spain.ORCID 0000-0001-5026-2701
Attila SzaboFaculty of Health and Sport Sciences, Széchenyi István University, H-9026 Győr, Hungary.ORCID 0000-0003-2788-4304
Mehmet Ali ErgünDepartment of Medical Genetics, Faculty of Medicine, Gaz University, Ankara 06560, Türkiye.ORCID 0000-0001-9696-0433
Luca Paolo ArdigòDepartment of Teacher Education, NLA University College, 0166 Oslo, Norway.ORCID 0000-0001-7677-5070

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesHandgrip strength (HGS) is a widely used indicator of upper-limb muscular strength and a practical proxy for neuromuscular performance across both clinical and athletic contexts. Although HGS is heritable, evidence supporting specific genetic contributors in elite athletes remains limited. Thus, the present study investigated the associations of two functional polymorphisms,

methodsThe present study included 613 subjects (56 elite male wrestlers (mean age: 22.35 ± 5.34 years; training experience: 13.40 ± 3.85 years) and 557 healthy individuals drawn from a public database). HGS measurements were performed using a digital hand dynamometer.

resultsGenotyping was performed on DNA extracted from peripheral blood using a high-density single nucleotide polymorphism (SNP) array. Neither

conclusionsThese findings suggest no detectable effects of single candidate variants on HGS under the current study design in highly trained athletes; however, this interpretation should be made cautiously given cohort-specific limitations and does not preclude their potential contribution within the broader polygenic architecture of strength-related traits. Future research employing larger, well-powered, and multi-cohort designs and polygenic approaches is warranted to further elucidate the genetic basis of strength phenotypes.

Indexed as

ActininBrain-Derived Neurotrophic FactorHand StrengthPolymorphism, Single NucleotideWrestlingAdolescentAdultAthletesHumansMaleYoung AdultActininACTN3 protein, humanBDNF protein, humanBrain-Derived Neurotrophic FactorACTN3athletesBDNFhandgrip strengthwrestlers

Identifiers

PMID42195016
PMCPMC13205741

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.