ArticleGenes2026
Transcriptomic Insights into the Association of IL-1 Signaling with the Senescence-Associated Secretory Phenotype in Human Fibroblasts.
Article in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
BACKGROUND/
objectivesCellular senescence is a stable growth-arrested state accompanied by the senescence-associated secretory phenotype (SASP), a complex inflammatory secretome that contributes to tissue remodeling, chronic inflammation, and age-related disease. Although multiple signaling pathways have been implicated in SASP regulation, the extent to which interleukin-1 (IL-1) signaling is associated with the organization of SASP-associated transcriptional programs remains incompletely defined at the transcriptomic level.
methodsHere, we performed a focused in silico analysis of a publicly available RNA-sequencing dataset (GSE63577) profiling primary human fibroblasts undergoing replicative senescence. Differential expression analysis revealed broad inflammatory remodeling in senescent fibroblasts, including robust upregulation of canonical SASP-associated cytokines, chemokines, and matrix-related factors. Targeted visualization using a curated, literature-defined SASP gene panel confirmed consistent transcriptional activation of key SASP components during replicative senescence.
resultsTo assess transcriptional associations, we performed correlation-based network analysis centered on
conclusionsTogether, these findings suggest that IL-1 signaling is consistently associated with a central position within the SASP-associated transcriptional network during replicative senescence in human fibroblasts. Therefore, the present study contributes transcriptomic network-level evidence supporting an association between IL-1 signaling and coordinated SASP-associated inflammatory programs, and highlights its potential relevance for intervention strategies.
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