Evidence map›Paper›PMID 42194302›Full record

ArticleBioengineering (Basel, Switzerland)2026

Development and Validation of an In Vitro Ocular Irritation Test for Ophthalmic Medical Devices with a Novel Reconstructed Human Corneal Epithelium Model.

Payal Rawat, Umberto Rodella, Stefania D'Agostino, Eugenio Ragazzi, Orietta Rossi, Claudio Gatto, Laura Giurgola, Jana D'Amato Tóthová

Abstract read
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Payal RawatResearch and Development, AL.CHI.MI.A. S.R.L., Moria Group, 35020 Ponte San Nicolò, Italy.ORCID 0009-0001-7271-2758
Umberto RodellaResearch and Development, AL.CHI.MI.A. S.R.L., Moria Group, 35020 Ponte San Nicolò, Italy.ORCID 0000-0002-4910-1617
Stefania D'AgostinoFondazione Banca Degli Occhi del Veneto ETS (FBOV), 30174 Venice, Italy.ORCID 0000-0001-6938-6851
Eugenio RagazziStudium Patavinum, University of Padova, 35122 Padova, Italy.ORCID 0000-0002-0390-6823
Orietta RossiQuality Control, AL.CHI.MI.A. S.R.L., Moria Group, 35020 Ponte San Nicolò, Italy.ORCID 0000-0002-0760-3723
Claudio GattoResearch and Development, AL.CHI.MI.A. S.R.L., Moria Group, 35020 Ponte San Nicolò, Italy.ORCID 0000-0003-4960-3614
Laura GiurgolaResearch and Development, AL.CHI.MI.A. S.R.L., Moria Group, 35020 Ponte San Nicolò, Italy.ORCID 0000-0002-1949-5213
Jana D'Amato TóthováResearch and Development, AL.CHI.MI.A. S.R.L., Moria Group, 35020 Ponte San Nicolò, Italy.ORCID 0000-0003-1498-615X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For testing ocular irritation, 3D corneal models mimicking the corneal epithelium are considered reliable eye irritation tests and are detailed in regulatory guideline OECD Test Guideline (TG) 492. The aim of the present study was to develop and validate a Reconstructed human Cornea-like Epithelium (RhCE)

Indexed as

3D in vitro model3Rs principleAir–Liquid Interfacein vitro eye irritation testingOECD Test Guideline 492

Identifiers

PMID42194302
PMCPMC13203266

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.