ArticleBioengineering (Basel, Switzerland)2026
Automatic Localization of Stable Highest Dominant Frequency Area in AF Patients Based on Spatial Aggregation.
Article in Bioengineering (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAtrial electrical activity in patients with persistent atrial fibrillation (PeAF) is extremely complex, and identifying optimal ablation targets during ablation procedures remains a significant challenge. This manuscript aims to identify spatiotemporally stable highest dominant frequency (HDF) in the left atrium to provide a reliable basis for Electrophysiologists to locate ablation targets beyond pulmonary veins.
methodsFiltering and spectral estimation were performed on the left atrial intracardiac electrogram (LA-EGM) of PeAF patients to recognize the dominant frequency (DF). Spatiotemporally stable DF features within the left atrium were extracted using spatial aggregation and others to construct a 3D DF distribution model. HDF areas were automatically identified based on personalized thresholds derived from the patient's DF distribution.
resultsData analysis of 43 PeAF patients demonstrated that spatial aggregation with 2 mm voxel size accurately constructs spatiotemporally stable DF distribution models. The proposed DF model enables the automatic identification of stable HDF areas in PeAF patients. In retrospective clinical cases, 72.1% of patients underwent ablation at these identified sites with effective therapeutic outcomes.
conclusionRecurring HDF areas during PeAF serve as potential ablation targets. The results of this study provide a reliable basis for determining personalized ablation targets for PeAF patients.
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