Evidence map›Paper›PMID 42194255›Full record

ArticleBioengineering (Basel, Switzerland)2026

Meso-Scale Modifications in Additively Manufactured Zirconia: Topographical Design and Its Influence on Cell-Material Interactions.

Sebastian Hetzler, Stefan Rues, Andreas Zenthöfer, Peter Rammelsberg, Reinald Kühle, Christopher J Lux, Ralf Erber, Christoph J Roser

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sebastian HetzlerDepartment of Prosthodontics, Medical Faculty, Heidelberg University, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.ORCID 0009-0000-3724-1607
Stefan RuesDepartment of Prosthodontics, Medical Faculty, Heidelberg University, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.ORCID 0000-0001-9515-4405
Andreas ZenthöferDepartment of Prosthodontics, Medical Faculty, Heidelberg University, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.
Peter RammelsbergDepartment of Prosthodontics, Medical Faculty, Heidelberg University, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.
Reinald KühleDeparment of Craniomaxillofacial Surgery, Medical Facutly, Heidelberg University, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.ORCID 0000-0002-9941-6772
Christopher J LuxDepartment of Orthodontics and Dentofacial Orthopedics, Medical Faculty, Heidelberg University, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.ORCID 0000-0002-6995-5572
Ralf ErberDepartment of Orthodontics and Dentofacial Orthopedics, Medical Faculty, Heidelberg University, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.ORCID 0000-0001-9689-2151
Christoph J RoserDepartment of Orthodontics and Dentofacial Orthopedics, Medical Faculty, Heidelberg University, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.ORCID 0000-0002-7556-1510

Funding

Deutsche Forschungsgemeinschaft 524875261
6 · The paper itself

Abstract

Additive manufacturing enables the fabrication of patient-specific zirconia devices with integrated surface features; however, the biological effects of meso-scale topographies remain insufficiently understood. This in vitro study evaluated the influence of defined meso-scale surface modifications on osteoblast behavior using Digital Light Processing (DLP)-fabricated 3Y tetragonal zirconia polycrystal (3Y-TZP) and 5Y partially stabilized zirconia (5Y-PSZ). Planar control specimens and surfaces incorporating regularly distributed columnar structures (height: 100 µm; width: 40 µm; center-to-center spacing: 80, 120, and 160 µm; Mod-80, Mod-120, Mod-160) were fabricated and characterized after sintering. Cytotoxicity was assessed by elution testing and showed cell viability >98% for all groups. Osteoblast adhesion and proliferation (hFOB 1.19) were quantified using metabolic assays. Meso-scale modifications significantly increased early cell adhesion compared to planar controls (

Indexed as

3Y-TZP5Y-PSZadditive manufacturingcell–material interactiondental implantsdigital light processing (DLP)meso-scale surface topographyosteoblast adhesionosteogenic differentiationpersonalized dentistryregenerative medicinezirconia

Identifiers

PMID42194255
PMCPMC13203704

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.