ArticleChildren (Basel, Switzerland)2026
Multimodal Assessment of Cerebral Perfusion and EEG Maturation in Preterm Infants at Term-Equivalent Age.
Article in Children (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
objectivePreterm birth poses notable neurodevelopmental risks, with cerebral microcirculatory disturbances potentially contributing to long-term impairment. Existing monitoring modalities lack bedside capacity to evaluate these microvascular changes during critical brain development. We characterized cerebral microperfusion and functional maturation patterns in preterm versus full-term neonates using combined ultra-micro angiography (UMA) and an amplitude-integrated electroencephalogram (aEEG).
methodsIn this prospective study, 76 neonates (23 extremely/very preterm [EP/VPT], 27 moderate-late preterm, and 26 term controls) were assessed at term-equivalent age. UMA helped quantify regional microperfusion (color pixel percentage, abbreviated as CPP in this context to differentiate from cerebral perfusion pressure), whereas aEEG (Burdjalov scores) helped evaluate functional maturation at 37-38 and 40 weeks' postmenstrual age.
resultsEP/VPT infants demonstrated significant cerebral hyperperfusion with distinct cortex-white matter perfusion gradients. Although preterm infants showed advanced aEEG maturation at 37-38 weeks, this difference normalized by 40 weeks.
conclusionGestation-dependent cerebral hyperperfusion and transient EEG maturation differences in EP/VPT infants at term-equivalent age support the value of UMA-aEEG integration for neurovascular assessment. The observed perfusion-EEG patterns suggest prematurity-specific neuroadaptation, warranting further investigation of long-term functional correlates.
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