Evidence map›Paper›PMID 42194138›Full record

ReviewChildren (Basel, Switzerland)2026

Down Syndrome Births Among Live Births from the CDC Wonder Database.

Stephanie L Santoro, Chance Alvarado, Stephen A Hart, Thomas Casto, Clifford L Cua

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Children (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Stephanie L SantoroMassachusetts General Hospital, Boston, MA 02114, USA.
Chance AlvaradoNationwide Children's Hospital Heart Center, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Stephen A HartNationwide Children's Hospital Heart Center, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Thomas CastoNationwide Children's Hospital Heart Center, Nationwide Children's Hospital, Columbus, OH 43205, USA.ORCID 0009-0005-9409-6377
Clifford L CuaNationwide Children's Hospital Heart Center, Nationwide Children's Hospital, Columbus, OH 43205, USA.ORCID 0000-0002-9172-3874

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We evaluated the birth rate of Down syndrome (DS) in the CDC birth certificate online database. From 2016 to 2025, live birth incidence could range greatly (depending on the proportion of unknown cases that are counted as DS+) due to relatively high numbers of unknown/not stated status. The annual live birth incidence of DS in live-born infants using CDC birth certificate data from 2016 to 2025 shows a wide range of potential birth rates as calculated here, due to relatively high numbers of unknown/not stated DS status. Although our findings overlap with published data, future studies are needed to further evaluate the current birth rate of DS in the US.

Indexed as

birth rateDown syndrome

Identifiers

PMID42194138
PMCPMC13204170

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.