Compound Augmentation of Myocardial Injury in a Rat Model of Coronary Heart Disease Induced by Ischemia/Reperfusion, Rheumatoid Arthritis, and High-Fat Diet: A Molecular Mechanistic Study.

Qixiang Xu, Jin Zhang, Lvming Li, Zhen Zhang, Zui Pan, Yongqiu Zheng

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Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Qixiang XuProvincial Engineering Laboratory for Screening and Re-Evaluation of Active Compounds of Herbal Medicines in Southern Anhui, Wannan Medical University, Wuhu 241002, China.ORCID 0000-0001-7848-5130

Jin ZhangBeijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.ORCID 0000-0002-2404-058X

Lvming LiProvincial Engineering Laboratory for Screening and Re-Evaluation of Active Compounds of Herbal Medicines in Southern Anhui, Wannan Medical University, Wuhu 241002, China.ORCID 0009-0006-4552-0087

Zhen ZhangProvincial Engineering Laboratory for Screening and Re-Evaluation of Active Compounds of Herbal Medicines in Southern Anhui, Wannan Medical University, Wuhu 241002, China.ORCID 0009-0000-0085-0345

Zui PanBone-Muscle Research Center, College of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, TX 76019, USA.ORCID 0000-0003-4105-901X

Yongqiu ZhengProvincial Engineering Laboratory for Screening and Re-Evaluation of Active Compounds of Herbal Medicines in Southern Anhui, Wannan Medical University, Wuhu 241002, China.ORCID 0000-0002-4916-4829

Funding

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6 · The paper itself

Abstract

aimsCoronary heart disease (CHD) associated with rheumatoid arthritis (RA) is a primary driver of mortality in RA patients. In this study, we sought to establish a combined rat model of CHD and RA by integrating cardiac ischemia/reperfusion (I/R), high-fat diet (HFD), and intradermal administration of bovine type II collagen emulsified in complete Freund's adjuvant. The aim of constructing this model is to investigate and analyze the pathogenesis of RA-induced CHD under the modulation of HFD and cardiac I/R exposure. METHODS AND

resultsSixty-four male Sprague-Dawley rats were randomly categorized into eight groups (

conclusionsWe successfully established a rat model of CHD with rheumatic syndrome using I/R in combination with RA and HFD. The present findings suggest that the PTRF-related TLR4/MyD88-JNK signaling pathway may act as an important regulatory mechanism underlying myocardial injury aggravated by combined HFD and CIA stimulation.

Indexed as

Arthritis, RheumatoidCoronary DiseaseDiet, High-FatMyocardial Reperfusion InjuryAnimalsDisease Models, AnimalMaleMyeloid Differentiation Factor 88MyocardiumRatsRats, Sprague-DawleySignal TransductionToll-Like Receptor 4Myeloid Differentiation Factor 88Toll-Like Receptor 4coronary heart diseasePTRFrheumatoid arthritisTLR4/MyD88

Identifiers

PMID42194101

DOI10.3390/biom16050753

PMCPMC13204909

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