Evidence map›Paper›PMID 42194084›Full record

ArticleBiomolecules2026

An Ex Vivo Model of Post Infectious Bronchiolitis Obliterans in Children Using Reconstituted Human Bronchial Epithelium.

Julie Mazenq, Léa Moreno, Jean-Christophe Dubus, Fabien Chuette, Louisa Goumidi, Nicoleta Panait, Pascal Chanez, Delphine Gras

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Julie MazenqPediatric Pulmonology Department and Reference Center for Rare Lung Disease RespiRare, Assistance Publique des Hôpitaux de Marseille (AP-HM), Hôpital Universitaire Timone-Enfants, 13385 Marseille, France.ORCID 0000-0002-8257-7107
Léa MorenoPediatric Pulmonology Department, Aix-Marseille University, INSERM, INRAE, C2VN, 13005 Marseille, France.
Jean-Christophe DubusPediatric Pulmonology Department and Reference Center for Rare Lung Disease RespiRare, Assistance Publique des Hôpitaux de Marseille (AP-HM), Hôpital Universitaire Timone-Enfants, 13385 Marseille, France.ORCID 0000-0003-2078-4140
Fabien ChuettePediatric Pulmonology Department, Aix-Marseille University, INSERM, INRAE, C2VN, 13005 Marseille, France.
Louisa GoumidiPediatric Pulmonology Department, Aix-Marseille University, INSERM, INRAE, C2VN, 13005 Marseille, France.
Nicoleta PanaitPediatric Surgery Department, Marseille Public University Hospital System, 13354 Marseille, France.
Pascal ChanezPediatric Pulmonology Department, Aix-Marseille University, INSERM, INRAE, C2VN, 13005 Marseille, France.
Delphine GrasPediatric Pulmonology Department, Aix-Marseille University, INSERM, INRAE, C2VN, 13005 Marseille, France.ORCID 0000-0002-6630-2955

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPost-infectious bronchiolitis obliterans (PIBO) is a rare and severe chronic lung disease. Our goal was to characterize respiratory epithelium in children with PIBO, which remains unexplored, using an ex vivo model culture.

methodsProximal bronchial biopsies from children with PIBO and reconstituted bronchial epithelium from PIBO patients (

resultsEpithelial thickness was assessed in PIBO biopsies. Ex vivo reconstituted PIBO epithelia appeared to exhibit comparable cohesion and cell composition to controls. Mucin expression and secretion were likewise similar between groups. PIBO epithelial might have displayed reduced IL-33 transcript levels and decreased TSLP secretion, whereas IFN-λ1, IFN-λ2-3 and IFN-β secretion could have been elevated. No differences were detected in remodeling markers (MMP-9 and YKL-40).

conclusionsIn summary, ex vivo model of PIBO epithelia suggested that the epithelium may preserve structural characteristics and mucin production, without evidence of remodeling. However, PIBO epithelial cells may have a distinct immune profile, with lower alarmin expression and higher interferon secretion. This could indicate a tendency toward enhanced antiviral response rather than structural changes. These preliminary results need to be confirmed in larger cohorts.

Indexed as

BronchiBronchiolitis ObliteransRespiratory MucosaChildChild, PreschoolCytokinesEpithelial CellsFemaleHumansMaleMucinsCytokinesMucinsalarminsbronchial epitheliumchildreninterferonpost-infectious bronchiolitis obliterans

Identifiers

PMID42194084
PMCPMC13205076

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.