Evidence map›Paper›PMID 42194065›Full record

ArticleBiomolecules2026

High-Affinity Nanobody Against the LEDGF PWWP Domain Inhibits Chromatin Binding In Vitro.

Thibault Vantieghem, Sofie Jansen, Thatcher Zinabu Akele, Pieterjan Van Maele, Sam Noppen, Dominique Schols, Maarten Dewilde, Zeger Debyser, Sergei V Strelkov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Thibault VantieghemBiocrystallography, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-1452-9584
Sofie JansenBiocrystallography, KU Leuven, 3000 Leuven, Belgium.
Thatcher Zinabu AkeleAdvanced Disease Modelling, Targeted Drug Discovery and Gene Therapy (ADVANTAGE), KU Leuven, 3000 Leuven, Belgium.
Pieterjan Van MaeleLaboratory for Therapeutic and Diagnostic Antibodies, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-0460-1976
Sam NoppenMolecular, Structural and Translational Virology, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-2831-5042
Dominique ScholsMolecular, Structural and Translational Virology, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0003-3256-5850
Maarten DewildeLaboratory for Therapeutic and Diagnostic Antibodies, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-3138-281X
Zeger DebyserAdvanced Disease Modelling, Targeted Drug Discovery and Gene Therapy (ADVANTAGE), KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-3982-1565
Sergei V StrelkovBiocrystallography, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0001-7189-4652

Funding

KU Leuven C32/18/038Research Foundation - Flanders 1S11223NResearch Foundation - Flanders 1SC9822NResearch Foundation - Flanders 1SC9824NResearch Foundation - Flanders 1SF0324NResearch Foundation - Flanders G053822NResearch Foundation - Flanders I007220N
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adaptor Proteins, Signal TransducingChromatinIntercellular Signaling Peptides and ProteinsSingle-Domain AntibodiesAnimalsCamelids, New WorldCrystallography, X-RayHistonesHumansProtein BindingProtein DomainsAdaptor Proteins, Signal TransducingChromatinHistonesIntercellular Signaling Peptides and Proteinslens epithelium-derived growth factorSingle-Domain Antibodiesbinding studychromatin readerepigeneticsinhibitorLEDGF/p75nanobodyprotein–protein interactionPWWP domainsingle-domain antibodyVHH

Identifiers

PMID42194065
PMCPMC13204740

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.