Evidence map›Paper›PMID 42194045›Full record

ArticleBiomolecules2026

Effects of Loop Nucleobase Substitution on G-Quadruplex Thermal Stability in Aqueous Glycine Betaine, Proline, TMAO, and Urea Solutions.

Jeffrey J Schwinefus, Marija Corluka, Isabella Dobrinski, Stella L Jaeckle, Joshua Kim, Grace Knowlan, Hannah Omodt, Noah Otto, Mari V Reid, Reid Rognerud and 1 more

Abstract read
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jeffrey J SchwinefusDepartment of Chemistry, St. Olaf College, Northfield, MN 55057, USA.ORCID 0000-0002-8212-9902
Marija CorlukaDepartment of Chemistry, St. Olaf College, Northfield, MN 55057, USA.ORCID 0009-0001-4082-8879
Isabella DobrinskiDepartment of Chemistry, St. Olaf College, Northfield, MN 55057, USA.
Stella L JaeckleDepartment of Chemistry, St. Olaf College, Northfield, MN 55057, USA.
Joshua KimDepartment of Chemistry, St. Olaf College, Northfield, MN 55057, USA.
Grace KnowlanDepartment of Chemistry, St. Olaf College, Northfield, MN 55057, USA.
Hannah OmodtDepartment of Chemistry, St. Olaf College, Northfield, MN 55057, USA.
Noah OttoDepartment of Chemistry, St. Olaf College, Northfield, MN 55057, USA.ORCID 0009-0003-4562-3682
Mari V ReidDepartment of Chemistry, St. Olaf College, Northfield, MN 55057, USA.ORCID 0000-0002-6638-038X
Reid RognerudDepartment of Chemistry, St. Olaf College, Northfield, MN 55057, USA.ORCID 0009-0002-5104-1235
Kathryn M SteinDepartment of Chemistry, St. Olaf College, Northfield, MN 55057, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

G-quadruplexes are guanine-rich DNA or RNA structures comprising two or more stacked guanine tetrads (G-quartet) with nucleobases in the loops linking the G-quartets. The thermal stability of the thrombin-binding aptamer G2 d(G

Indexed as

BetaineG-QuadruplexesMethylaminesProlineUreaAptamers, NucleotideSolutionsTemperatureThermodynamicsWaterAptamers, NucleotideBetaineMethylaminesProlineSolutionstrimethyloxamineUreaWaterglycine betaineG-quadruplexprolinethermal stabilityTMAOurea

Identifiers

PMID42194045
PMCPMC13204723

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.