Evidence map›Paper›PMID 42194025›Full record

ArticleBiomolecules2026

Deciphering Lipid Metabolic Landscape of Sorafenib-Treated Hepatocellular Carcinoma by Mass Spectrometry Imaging and Transcriptomics.

Dongsheng Li, Yuanyuan Tuo, Luheng Sai, Xiunan Xu, Fujuan Peng, Zhipeng Yan, Qin Yang, Huifang Zhao, Ruiping Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dongsheng LiFirst Clinical Medical School, Shanxi Medical University, Taiyuan 030001, China.
Yuanyuan TuoSchool of Basic Medical Sciences, Academy of Medical Sciences, Research Institute of Circadian Rhythm and Disease, Shanxi Medical University, Taiyuan 030001, China.
Luheng SaiSchool of Basic Medical Sciences, Academy of Medical Sciences, Research Institute of Circadian Rhythm and Disease, Shanxi Medical University, Taiyuan 030001, China.
Xiunan XuSchool of Basic Medical Sciences, Academy of Medical Sciences, Research Institute of Circadian Rhythm and Disease, Shanxi Medical University, Taiyuan 030001, China.
Fujuan PengSchool of Basic Medical Sciences, Academy of Medical Sciences, Research Institute of Circadian Rhythm and Disease, Shanxi Medical University, Taiyuan 030001, China.
Zhipeng YanShanxi Provincial People's Hospital, Fifth Hospital of Shanxi Medical University, Taiyuan 030012, China.
Qin YangShanxi Provincial People's Hospital, Fifth Hospital of Shanxi Medical University, Taiyuan 030012, China.
Huifang ZhaoSchool of Basic Medical Sciences, Academy of Medical Sciences, Research Institute of Circadian Rhythm and Disease, Shanxi Medical University, Taiyuan 030001, China.
Ruiping ZhangShanxi Provincial People's Hospital, Fifth Hospital of Shanxi Medical University, Taiyuan 030012, China.ORCID 0000-0001-6922-0747

Funding

Ministry of Science and Technology 2023YFC3402800Ministry of Science and Technology 2024ZD0531100National Natural Science Foundation of China 22004082Science and Technology Department of Shanxi Province 202503021211127Science and Technology Department of Shanxi Province 202503021212345Shanxi Medical University XD1907Shanxi Provincial Department of Education 2025L040Shanxi Provincial Department of Education 2025Q013
6 · The paper itself

Abstract

Although sorafenib (SOR) is effective for advanced hepatocellular carcinoma (HCC), significant metabolic heterogeneity limits its therapeutic effect. In this study, we employed high-resolution matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) to profile the spatial lipidomic alterations in 3D HepG2 spheroids following SOR treatment. Interestingly, sphingophospholipid and glycerophospholipid metabolism played crucial roles. In an orthotopic HCC mouse model, immunohistochemical and immunofluorescence staining confirmed that SOR induced immunological and inflammatory changes. Moreover, transcriptomic and Q-PCR analyses showed increased expression of

Indexed as

Antineoplastic AgentsCarcinoma, HepatocellularLipid MetabolismLiver NeoplasmsSorafenibTranscriptomeAnimalsGene Expression Regulation, NeoplasticHep G2 CellsHumansLipidomicsMiceMolecular Docking SimulationSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationAntineoplastic AgentsSorafenibhepatocellular carcinomalipid reprogrammingMALDI MSIsorafenibtranscriptomics

Identifiers

PMID42194025
PMCPMC13204014

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.