Evidence map›Paper›PMID 42194004›Full record

ArticleBiomolecules2026

High-Definition Brain Network (HDBN) Delineation of CDKL5 Deficiency Disorder (CDD) in Genetically Engineered Mice.

Dalton West, Noah William Coulson, Devin Raine Everaldo Cortes, Kristina Elsa Schwab, Thomas Becker-Szurszewski, Sean Hartwick, Margaret Caroline Stapleton, Gabriella Marie Saladino, Cecilia Wen-Ya Lo, Christina M Patterson and 3 more

Abstract read
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In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dalton WestDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.ORCID 0009-0006-9902-525X
Noah William CoulsonDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.
Devin Raine Everaldo CortesDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.ORCID 0009-0004-8130-8513
Kristina Elsa SchwabDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.
Thomas Becker-SzurszewskiDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.ORCID 0009-0008-0540-4289
Sean HartwickDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.ORCID 0009-0006-2474-5623
Margaret Caroline StapletonDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.ORCID 0009-0008-1241-045X
Gabriella Marie SaladinoDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.
Cecilia Wen-Ya LoDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.ORCID 0000-0003-4314-3434
Christina M PattersonDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.ORCID 0000-0003-0608-8181
Subramanian SubramanianUPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.ORCID 0000-0003-2185-1931
Deepa Soundara RajanDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.
Yijen Lin WuDepartment of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.ORCID 0000-0001-9509-5417

Funding

American Heart Association 18CDA34140024NIH Common Fund R21-EB023507NIH Common Fund R21-NS121706NIH Common Fund R21-NS142555United States Department of Defense W81XWH1810070United States Department of Defense W81XWH-22-1-0221
6 · The paper itself

Abstract

Cyclin-Dependent Kinase-Like 5 (CDKL5) Deficient Disorder (CDD) is a rare X-linked developmental and epileptic encephalopathy characterized by early-onset refractory epilepsy, severe neurodevelopmental impairment, and lifelong disability. Although more than thirty anti-seizure medications are available, most CDD patients remain pharmaco-resistant. Gene-based therapies are emerging, but therapeutic development is hindered by marked clinical heterogeneity, small patient populations, and the lack of robust, translatable brain-based biomarkers for clinical trials. Genetically engineered

Indexed as

BrainEpileptic SyndromesNerve NetProtein Serine-Threonine KinasesSpasms, InfantileAnimalsDiffusion Tensor ImagingDisease Models, AnimalGenetic EngineeringMaleMiceMice, KnockoutCDKL5 protein, mouseProtein Serine-Threonine Kinasesbrain networkCDDCDKL5diffusion tensor imagingMRIneurodevelopment

Identifiers

PMID42194004
PMCPMC13204541

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.