ArticleBiomolecules2026
Maternal Acrylamide Exposure Modulates Parvalbumin-Positive Interneurons in the Subiculum and Hippocampus of Rat Offspring.
Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Rutin attenuates acrylamide-induced oxidative liver injury.Molecular biology reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acrylamide is a neurotoxic compound formed during thermal food processing that can cross the placental barrier and potentially affect fetal brain development. This study aimed to evaluate the effects of maternal acrylamide exposure on parvalbumin-immunoreactive (PV-IR) neurons in the pyramidal layer of the subiculum (Sub) and hippocampus of weaning rats. Pregnant Wistar rats received 3 mg/kg b.w. of acrylamide orally for 5 or 10 days during the prenatal period. After weaning, offspring brains were analyzed using immunohistochemistry, morphometry, and quantitative assessment of PV-IR neuron density and staining intensity in the pyramidal layers of the Sub, Cornu Ammonis 1 (CA1), and Cornu Ammonis 3 (CA3). The results demonstrated a significant increase in PV-IR neuron density in the Sub and CA1 after prolonged maternal exposure, accompanied by a predominance of weakly stained cells and decreased mean immunostaining intensity. Morphometric analyses revealed region-specific changes: enlarged cell area and perimeter with reduced nuclear-to-cytoplasmic ratio in the Sub, whereas CA1 and CA3 showed smaller cell dimensions and altered shapes. In conclusion, maternal acrylamide exposure is associated with region-dependent alterations in the morphology and immunoreactivity of PV-IR neurons within the offspring hippocampus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.