Evidence map›Paper›PMID 42193974›Full record

ArticleBiomolecules2026

Crystallography of Extremophile Proteins-Structural Comparisons of Psychrophilic and Hyperthermophilic Rubredoxins.

Tzanko Doukov, Trenton F Turpin, Dominic George, Caroline Cole, Kat Drumright, Madigan Rumley, Ryan Boyce, Francis E Jenney, Stephen P Cramer

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tzanko DoukovSLAC National Laboratory, SSRL, Menlo Park, CA 94025, USA.ORCID 0000-0001-8625-2572
Trenton F TurpinUniversity of Texas, Austin, TX 78712, USA.ORCID 0009-0006-1051-1818
Dominic GeorgeUniversity of Saskatchewan, Saskatoon, SK S7N 5A2, Canada.ORCID 0009-0002-6548-2779
Caroline ColeUniversity of Texas, Austin, TX 78712, USA.ORCID 0009-0002-4283-265X
Kat DrumrightUniversity of California, Davis, CA 95616, USA.ORCID 0009-0004-7645-7047
Madigan RumleyUniversity of Colorado-Boulder, Boulder, CO 80309, USA.ORCID 0000-0002-8021-7562
Ryan BoyceBIomedical Science, Philadelphia College of Osteopathic Medicine, Georgia Campus, Suwanee, GA 30024, USA.ORCID 0009-0009-3841-8043
Francis E JenneyBIomedical Science, Philadelphia College of Osteopathic Medicine, Georgia Campus, Suwanee, GA 30024, USA.ORCID 0000-0002-1667-6924
Stephen P CramerSETI Institute, Mountain View, CA 94043, USA.ORCID 0000-0002-3751-7623

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Ritimukta Sarangi · 2020 to 2026
$43.3M
X-Ray Raman and Vibrational Mossbauer of MetalloproteinsR01GM065440 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI CRAMER, STEPHEN P. · 2002 to 2025
$7.3M
NIGMS NIH HHS P30 GM133894NIGMS NIH HHS R01 GM065440NIH HHS GM-65440NSF MCB-2149122
6 · The paper itself

Abstract

Psychrophilic organisms are able to grow at temperatures down to -15 °C, while hyperthermophiles can multiply at temperatures up to 122 °C. What structural changes in extremophile proteins are needed to maintain stable and biochemically active structures under such conditions? Understanding how such extremophiles accomplish this is relevant for human health, biotechnology, and our search for life elsewhere in the universe. The purpose of the current study is to report and compare the structures of four rubredoxins (Rds), the first ever two experimental psychrophile bacteria structures (from Gram-positive

Indexed as

Bacterial ProteinsExtremophilesRubredoxinsCrystallography, X-RayModels, MolecularProtein ConformationThermotoga maritimaBacterial ProteinsRubredoxinsextremophilehyperthermophilepsychrophilerubredoxinX-ray diffraction

Identifiers

PMID42193974
PMCPMC13204472

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.