Evidence map›Paper›PMID 42193947›Full record

ArticleCells2026

Costunolide, a Sesquiterpene Lactone, Protects Against Platelet Activation and Thrombus Formation.

Joen-Rong Sheu, Kuan-Hung Lin, Ray-Jade Chen, Hao-Ping Chia, Ting-Yu Chen, Thanasekaran Jayakumar, Hsueh-Hsiao Wang, Hsien-Yu Peng, Jiun-Yi Li, Wan-Jung Lu

Abstract read
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Joen-Rong SheuGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.ORCID 0000-0001-8265-3678
Kuan-Hung LinInstitute of Biomedical Sciences, College of Medicine, MacKay Medical University, New Taipei City 252, Taiwan.ORCID 0000-0003-1519-1797
Ray-Jade ChenDepartment of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Hao-Ping ChiaDepartment of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Ting-Yu ChenInstitute of Biomedical Sciences, College of Medicine, MacKay Medical University, New Taipei City 252, Taiwan.
Thanasekaran JayakumarDepartment of Ecology and Environmental Sciences, Pondicherry University, Puducherry 605014, India.
Hsueh-Hsiao WangSchool of Medicine, College of Medicine, MacKay Medical University, New Taipei City 252, Taiwan.
Hsien-Yu PengSchool of Medicine, College of Medicine, MacKay Medical University, New Taipei City 252, Taiwan.
Jiun-Yi LiGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Wan-Jung LuDepartment of Optometry, College of Medicine, MacKay Medical University, New Taipei City 252, Taiwan.ORCID 0000-0001-7664-4740

Funding

MacKay Medical Hospital MMH-114-11MacKay Medical Hospital MMH-115-047MacKay Medical Hospital MMH-MM-114-11MacKay Medical Hospital MMH-MM-115-17MacKay Medical University MMU-RD-109-CF-G2-01MacKay Medical University MMU-RD-110-CF-G002-01MacKay Medical University MMU-RD-112-2A-P003National Science and Technology Council of Taiwan NSTC 109-2320-B-038-044-MY3National Science and Technology Council of Taiwan NSTC 109-2320-B-715-003-MY3National Science and Technology Council of Taiwan NSTC 110-2320-B-038-086National Science and Technology Council of Taiwan NSTC 111-2628-B-715-002-MY3National Science and Technology Council of Taiwan NSTC 111-2813-C-038-079-BNational Science and Technology Council of Taiwan NSTC 112-2320-B-715-004National Science and Technology Council of Taiwan NSTC 113-2320-B-195-002National Science and Technology Council of Taiwan NSTC 113-2320-B-715-002-MY3National Science and Technology Council of Taiwan NSTC 114-2302-B-038-033-MY3National Science and Technology Council of Taiwan NSTC 114-2320-B-715-002-MY3National Science and Technology Council of Taiwan NSTC 114-2811-B-715-004
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

LactonesPlatelet ActivationSesquiterpenesThrombosisAnimalsBlood PlateletsCalciumCollagenHumansMaleMiceMice, Inbred C57BLPlatelet AggregationPlatelet Aggregation InhibitorsCalciumCollagencostunolideLactonesPlatelet Aggregation InhibitorsSesquiterpenescardiovascular diseasescostunolideGPVIplatelet activationthrombus formation

Identifiers

PMID42193947
PMCPMC13204036

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.