In one paragraphArticle in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Rikuto FujitaDepartment of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan.ORCID 0009-0004-0623-7989 Takashi IshinoDepartment of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan.ORCID 0000-0002-0646-0839 Takashi OdaDepartment of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan.
Tomohiro KawasumiDepartment of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan.ORCID 0000-0001-8121-2731 Manabu NishidaDepartment of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan.
Yuichiro HoribeDepartment of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan.
Nobuyuki ChikuieDepartment of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan.
Takayuki TaruyaDepartment of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan.ORCID 0000-0002-5873-9946 Takao HamamotoDepartment of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan.ORCID 0000-0001-9728-1264 Tsutomu UedaDepartment of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan.ORCID 0000-0001-9771-3880 Sachio TakenoDepartment of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, Japan.ORCID 0000-0002-9853-2501 Funding
Japan Society for the Promotion of Science 22K09668Research Collaboration Fund with Universal Sound Design Inc. 0G20KA7383
6 · The paper itselfAbstract
backgroundEosinophilic chronic rhinosinusitis (ECRS) is characterized by refractory nasal polyps and severely impaired mucociliary clearance (MCC). The molecular mechanisms underlying the modulation of mucociliogenesis following IL-4/13 blockade with dupilumab remain poorly understood, notwithstanding its proven clinical efficacy.
methodsBulk RNA Barcoding and sequencing (BRB-seq) was performed on nasal polyp tissues collected from healthy controls (
resultsThe ciliary master regulatory hierarchy (e.g.,
conclusionsIL-4/13 blockade successfully restores the structural and directional "hardware" of the respiratory epithelium but fails to rectify the enzymatic "software" required for mucus degradation. This "residual molecular scar" may explain the persistent mucus hyperviscosity observed in some ECRS patients even after clinical polyp resolution.
Indexed as
CytokinesEosinophiliaInterleukin-13Interleukin-33Interleukin-4Mucociliary ClearanceRhinosinusitisChronic DiseaseCiliaFemaleHumansMaleSignal TransductionThymic Stromal LymphopoietinCytokinesIL33 protein, humanIL4 protein, humanInterleukin-13Interleukin-33Interleukin-4Thymic Stromal LymphopoietinTSLP protein, humaneosinophilic rhinosinusitisIL-33multiciliogenesisthymic stromal lymphopoietin (TSLP)type 2 inflammation
Identifiers
PMID42193919
PMCPMC13204112
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390