Astrocyte Diversity and Alcohol-Related Gliovascular Alterations in the Human Dorsal Striatum Revealed by Combined Morphometric and Ultrastructural Analyses.

Evalds Viguls, Anita Ilze Gulbe, Simons Svirskis, Valerija Groma, Sandra Skuja

Abstract read

In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Evalds VigulsDivision of the Biological Sciences, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA.ORCID 0009-0002-3551-0150

Anita Ilze GulbeJoint Laboratory of Electron Microscopy, Rīga Stradiņš University, Kronvalda Blvd. 9, LV-1010 Riga, Latvia.

Simons SvirskisInstitute of Microbiology and Virology, Rīga Stradiņš University, Ratsupites St. 5, LV-1067 Riga, Latvia.ORCID 0000-0001-6889-6390

Valerija GromaJoint Laboratory of Electron Microscopy, Rīga Stradiņš University, Kronvalda Blvd. 9, LV-1010 Riga, Latvia.ORCID 0000-0003-2616-2668

Sandra SkujaJoint Laboratory of Electron Microscopy, Rīga Stradiņš University, Kronvalda Blvd. 9, LV-1010 Riga, Latvia.ORCID 0000-0002-3589-9429

Funding

Riga Stradiņš University Scientist Grant No. RSU-ZG-2024/1-0022 "Development and piloting of automation for analysis of the blood-brain barrier using deep neural networks" of the project No. 5.2.1.1.i.0/2/24/I/CFLA/005 "RSU Internal and RSU with LASE External Consolidation".

6 · The paper itself

Abstract

Astrocytes are key regulators of neuronal, metabolic, and vascular homeostasis, yet their morphological diversity and involvement in alcohol-related brain pathology remain incompletely characterized. In this study, we investigated astrocytic morphology in the human striatum of control individuals and subjects with short- and long-term alcohol exposure using immunohistochemistry combined with Sholl-based morphometric analysis, and ultrastructural assessment. GFAP immunohistochemistry was used to identify astrocytes, assess their morphology, and manually quantify GFAP

Indexed as

AstrocytesCorpus StriatumEthanolAdultFemaleGlial Fibrillary Acidic ProteinGray MatterHumansMaleMiddle AgedWhite MatterEthanolGlial Fibrillary Acidic Proteinalcohol exposureastrocytesGFAP immunohistochemistryheterogeneityhuman striatumneurovascular interfaceSholl analysis

Identifiers

PMID42193902

DOI10.3390/cells15100892

PMCPMC13204211

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.