Evidence map›Paper›PMID 42193876›Full record

ArticleCells2026

Acidosis Drives Vasculogenic Mimicry in PDAC CSCs via Na+/H+ Exchanger Isoform 1 (NHE1) and Calcium Entry.

Maria Raffaella Greco, Francesca Fracasso, Stefania Cannone, Daria Di Molfetta, Marilena Ardone, Sharon Natasha Cox, Brunella Rita Ladogana, Daniela Isabel Abbrescia, Apollonia Tullo, Marianna Ranieri and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Maria Raffaella GrecoDepartment of Bioscience, Biotechnologies and Environment, University of Bari Aldo Moro, Via E. Orabona 4, 70126 Bari, Italy.
Francesca FracassoDepartment of Bioscience, Biotechnologies and Environment, University of Bari Aldo Moro, Via E. Orabona 4, 70126 Bari, Italy.
Stefania CannoneDepartment of Bioscience, Biotechnologies and Environment, University of Bari Aldo Moro, Via E. Orabona 4, 70126 Bari, Italy.
Daria Di MolfettaDepartment of Bioscience, Biotechnologies and Environment, University of Bari Aldo Moro, Via E. Orabona 4, 70126 Bari, Italy.ORCID 0000-0003-4696-9944
Marilena ArdoneDepartment of Bioscience, Biotechnologies and Environment, University of Bari Aldo Moro, Via E. Orabona 4, 70126 Bari, Italy.ORCID 0009-0005-4233-9920
Sharon Natasha CoxDepartment of Bioscience, Biotechnologies and Environment, University of Bari Aldo Moro, Via E. Orabona 4, 70126 Bari, Italy.ORCID 0000-0002-8488-440X
Brunella Rita LadoganaDepartment of Bioscience, Biotechnologies and Environment, University of Bari Aldo Moro, Via E. Orabona 4, 70126 Bari, Italy.
Daniela Isabel AbbresciaCNR Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Research Council (CNR), Via G. Amendola 122/0, 70126 Bari, Italy.ORCID 0000-0001-6303-0969
Apollonia TulloCNR Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Research Council (CNR), Via G. Amendola 122/0, 70126 Bari, Italy.ORCID 0000-0002-5081-4745
Marianna RanieriDepartment of Bioscience, Biotechnologies and Environment, University of Bari Aldo Moro, Via E. Orabona 4, 70126 Bari, Italy.ORCID 0000-0003-3118-5813
Stephan J ReshkinDepartment of Bioscience, Biotechnologies and Environment, University of Bari Aldo Moro, Via E. Orabona 4, 70126 Bari, Italy.ORCID 0000-0001-9757-5908
Rosa Angela CardoneDepartment of Bioscience, Biotechnologies and Environment, University of Bari Aldo Moro, Via E. Orabona 4, 70126 Bari, Italy.ORCID 0000-0002-2011-9135

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vasculogenic mimicry (VM) is the ability of cancer stem cells (CSCs) to express an endothelial-like phenotype and participate in tumor neovascularization via the formation of a blood-conducting, matrix-rich network. We previously reported that pancreatic ductal adenocarcinoma (PDAC) CSCs develop their VM phenotype via two interacting and coordinated factors that support the formation of the VM network: (i) the overexpression of genes for endothelial factors and vascular receptors and (ii) the very high secretion of numerous pro-angiogenic/growth factors. While microenvironmental acidosis (low pHe) is an important driver of tumor metastasis, especially in PDAC, and is a component of the CSC niche, its role in VM and the ion transporters involved remains unknown. As normal stem cell differentiation is regulated by Na

Indexed as

AcidosisCalciumCarcinoma, Pancreatic DuctalNeoplastic Stem CellsNeovascularization, PathologicPancreatic NeoplasmsSodium-Hydrogen Exchanger 1Cell Line, TumorHumansHydrogen-Ion ConcentrationTumor MicroenvironmentCalciumSLC9A1 protein, humanSodium-Hydrogen Exchanger 1acidosiscalcium signalingcancer stem cellsNHE1tumor microenvironmentvasculogenic mimicry

Identifiers

PMID42193876
PMCPMC13204406

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.