Evidence map›Paper›PMID 42193814›Full record

ArticleAnimals : an open access journal from MDPI2026

Pharmacokinetic Profiles of Pentoxifylline and Its 5-Hydroxyhexyl Metabolite Administered by Different Doses in Goats.

Orhan Corum, Tulay Avci, Mustafa Hitit, Pedro Marin, Mario Giorgi, Duygu Durna Corum, Devran Coskun, Serafettin Kartal, Hatice Rumeysa Ceyhan, Fatma Akin and 2 more

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Orhan CorumDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Hatay 31060, Türkiye.ORCID 0000-0003-3168-2510
Tulay AvciFaculty of Veterinary Medicine, University of Selcuk, Konya 42031, Türkiye.ORCID 0009-0005-0817-8182
Mustafa HititCollege of Agriculture, Food and Natural Resources, Prairie View University, Prairie View, TX 77446, USA.
Pedro MarinDepartment of Pharmacology, Faculty of Veterinary Medicine, University of Murcia, 30100 Murcia, Spain.ORCID 0000-0003-4849-4452
Mario GiorgiDepartment of Veterinary Sciences, University of Pisa, San Piero a Grado, 56121 Pisa, Italy.
Duygu Durna CorumDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Hatay 31060, Türkiye.
Devran CoskunDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Siirt, Siirt 56100, Türkiye.
Serafettin KartalDepartment of Veterinary Medicine, Samandag Vocational School, Hatay Mustafa Kemal University, Hatay 31800, Türkiye.
Hatice Rumeysa CeyhanDepartment of Veterinary Medicine, Health Services Vocational School, University of Osmaniye Korkut Ata, Osmaniye 80100, Türkiye.
Fatma AkinDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Siirt, Siirt 56100, Türkiye.
Ibrahim BuyuktaskapuluDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, Konya 42031, Türkiye.
Kamil UneyDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, Konya 42031, Türkiye.ORCID 0000-0002-8674-4873

Funding

Selçuk University 23401144
6 · The paper itself

Abstract

This study examined dose-dependent alterations in the pharmacokinetics of pentoxifylline (PTX) and its 5-hydroxyhexyl (M-I) metabolite in goats. Goats were administered PTX intravenously at doses of 10, 20, and 40 mg/kg. PTX and M-I plasma concentrations were quantified by HPLC. The t

Indexed as

5-hydroxyhexyl metabolitegoatsHPLCincreasing dosepentoxifyllinepharmacokinetics

Identifiers

PMID42193814
PMCPMC13203126

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.