Clinical Outcomes Following Intra-Articular Administration of Autologous Muscle-Derived Mesenchymal Stem Cells in Horses with Chronic Osteoarthritis: A Prospective Open-Label Study.

Didier Serteyn, Hélène Graide, Justine Ceusters, Maxime Vandersmissen, Alexandra Salciccia, Charlotte Sandersen, Jean-Philippe Lejeune

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In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Didier SerteynCenter for Oxygen Research and Development, Fundamental and Applied Research for Animals and Health, University of Liege, 4000 Liege, Belgium.

Hélène GraideCenter for Oxygen Research and Development, Fundamental and Applied Research for Animals and Health, University of Liege, 4000 Liege, Belgium.

Justine CeustersCenter for Oxygen Research and Development, Fundamental and Applied Research for Animals and Health, University of Liege, 4000 Liege, Belgium.

Maxime VandersmissenEquine Clinic, Faculty of Veterinary Medicine, University of Liege, 4000 Liege, Belgium.ORCID 0000-0001-5534-6541

Alexandra SalcicciaEquine Clinic, Faculty of Veterinary Medicine, University of Liege, 4000 Liege, Belgium.ORCID 0000-0001-5902-5040

Charlotte SandersenCenter for Oxygen Research and Development, Fundamental and Applied Research for Animals and Health, University of Liege, 4000 Liege, Belgium.ORCID 0000-0002-3404-2757

Jean-Philippe LejeuneEquine Research Center, 6698 Vielsalm, Belgium.

Funding

Revatis SA 000736

6 · The paper itself

Abstract

Mesenchymal stromal/stem cells (MSCs) are increasingly investigated as intra-articular therapies for equine osteoarthritis (OA), although most studies have focused on allogeneic or combination-based approaches. Evidence supporting the use of autologous MSCs as a stand-alone treatment remains limited. The present study evaluated the safety and clinical evolution following intra-articular administration of autologous muscle-derived MSCs (mdMSCs) in horses with naturally occurring chronic OA. Thirteen horses with confirmed clinical disease were included. Each affected joint received a single injection, with the administered cell dose adapted to joint size (1 × 10

Indexed as

clinical studieshorsemesenchymal stem cellsorthobiologicsosteoarthritis

Identifiers

PMID42193813

DOI10.3390/ani16101523

PMCPMC13203449

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.