Evidence map›Paper›PMID 42193787›Full record

ArticleAnimals : an open access journal from MDPI2026

Identification of CircRNA-Related ceRNA Networks in the Longissimus Dorsi of Yaks at Different Developmental Stages.

Binyan Yu, Xiaoming Ma, Xiaoyun Wu, Min Chu, Xian Guo, Yongfu La, Chunnian Liang, Ping Yan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Binyan YuAnimal Science Department, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730070, China.
Xiaoming MaAnimal Science Department, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730070, China.
Xiaoyun WuAnimal Science Department, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730070, China.
Min ChuAnimal Science Department, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730070, China.
Xian GuoAnimal Science Department, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730070, China.ORCID 0000-0003-2390-4777
Yongfu LaAnimal Science Department, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730070, China.ORCID 0000-0002-5659-4341
Chunnian LiangAnimal Science Department, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730070, China.
Ping YanAnimal Science Department, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730070, China.

Funding

Agricultural Science and Technology Innovation Program 25-LZIHPS-01National Beef Cattle Industrial Technology System CARS-37National Natural Science Foundation of China U23A20227Science and Technology Projects of Xizang Autonomous Region XZ202502ZY0046-1Technology Talent Innovation Project 2025-QN-030the Lanzhou Youth Science and the Guidance Fund for Local Science and Technology Development by the Central Committee of the Communist Party of China 25ZYJA008the Science, the Central Public-interest Scientific Institution Basal Research Fund 1610322024015
6 · The paper itself

Abstract

We investigated the expression profiles and functions of CircRNAs in the longissimus dorsi muscle of Datong yaks at different developmental stages, with the aim of clarifying their regulatory roles in skeletal muscle development. Samples of longissimus dorsi muscle were collected from Datong yaks at three developmental stages: 90-day-old fetuses, 6-month-old juveniles, and 3-year-old adults. High-throughput RNA sequencing was performed to identify CircRNAs. Differential expression analysis, along with GO and KEGG enrichment analyses, was conducted. A competing endogenous RNA (ceRNA) regulatory network was subsequently constructed to screen for core CircRNAs. A total of 17,027 CircRNAs were identified, with 6821 being differentially expressed. These differentially expressed CircRNAs showed significant enrichment in skeletal muscle development-related functions, such as sarcomere and calcium ion homeostasis, and were involved in key pathways, including the FoxO (Forkhead box O) and calcium signaling pathways. Construction of the ceRNA network revealed 20 core CircRNAs (e.g., CircRNA_10402 and CircRNA_15445), which may modulate the expression of 84 mRNAs by competing for binding with 42 miRNAs. This study preliminarily reveals the dynamic regulatory network of CircRNAs during skeletal muscle development in Datong yaks, providing new theoretical insights for understanding the molecular mechanisms underlying yak muscle development and for molecular breeding.

Indexed as

CircRNADatong yaklongissimus dorsiRNA sequencingskeletal muscle development

Identifiers

PMID42193787
PMCPMC13203615

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.