Evidence map›Paper›PMID 42193782›Full record

ArticleAnimals : an open access journal from MDPI2026

The Involvement of the PI3K/AKT Pathway in Zn Alleviation of Heat Stress-Induced Damage to Broiler Jejunal Organoids.

Weizhen Song, Weiyun Zhang, Xi Lin, Hsiao-Ching Liu, Jack Odle, Miles Todd See, Shengchen Wang, Xiaoyan Cui, Chuanlong Wang, Liyang Zhang and 1 more

Abstract read
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In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Weizhen SongPoultry Mineral Nutrition Laboratory, College of Animal Science and Technology, Yangzhou University, Yangzhou 225000, China.
Weiyun ZhangPoultry Mineral Nutrition Laboratory, College of Animal Science and Technology, Yangzhou University, Yangzhou 225000, China.
Xi LinDepartment of Animal Science, North Carolina State University, Raleigh, NC 27695, USA.ORCID 0000-0003-3911-9677
Hsiao-Ching LiuDepartment of Animal Science, North Carolina State University, Raleigh, NC 27695, USA.
Jack OdleDepartment of Animal Science, North Carolina State University, Raleigh, NC 27695, USA.ORCID 0000-0003-4965-2096
Miles Todd SeeDepartment of Animal Science, North Carolina State University, Raleigh, NC 27695, USA.ORCID 0000-0002-1762-0439
Shengchen WangPoultry Mineral Nutrition Laboratory, College of Animal Science and Technology, Yangzhou University, Yangzhou 225000, China.
Xiaoyan CuiPoultry Mineral Nutrition Laboratory, College of Animal Science and Technology, Yangzhou University, Yangzhou 225000, China.ORCID 0000-0003-0669-5790
Chuanlong WangPoultry Mineral Nutrition Laboratory, College of Animal Science and Technology, Yangzhou University, Yangzhou 225000, China.
Liyang ZhangMineral Nutrition Research Division, State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Xugang LuoPoultry Mineral Nutrition Laboratory, College of Animal Science and Technology, Yangzhou University, Yangzhou 225000, China.

Funding

Jiangsu Shuang Chuang Ren Cai program JSSCRC2021541Jiangsu Shuang Chuang Tuan Dui program JSSCTD202147Key International Cooperation Program of the National Natural Science Foundation of China 32120103011
6 · The paper itself

Abstract

The direct involvement of the phosphatidylinositol 3-kinase (PI3K)/serine threonine kinase (AKT) signaling pathway in the alleviation of the heat stress (HS)-induced damage to the integrity and barrier function of broiler jejunal organoids (JOs) by supplemental zinc (Zn) has not been confirmed. To verify it, two experiments were conducted in the present study. In experiment 1, the optimal concentrations of PI3K/AKT inhibitor (PI3K-IN-1) or agonist (YS-49) were screened. In experiment 2, the role of PI3K/AKT in Zn alleviation of HS-induced damage to JOs was evaluated with three JO types as control groups under baseline incubation temperature (40 °C) plus a 3 (JOs types) × 3 (Zn sources) factorial design under high temperature (44 °C). The results showed that the optimal concentrations of the PI3K-IN-1 and YS-49 for effectively inhibiting and promoting (

Indexed as

broiler jejunal organoidscell proliferationheat stress-induced damagePI3K/AKT signaling pathwayzinc

Identifiers

PMID42193782
PMCPMC13203795

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.