Evidence map›Paper›PMID 42193736›Full record

ArticleAnimals : an open access journal from MDPI2026

Rumen-Protected Taurine Alleviates Heat Stress Injury in Hu Sheep by Regulating Inflammatory Response, Gut Microbiota and Transcriptome.

Yuting Wei, Yang Zhang, Xin Liu, Xinyu Chen, Guwei Lu, Yijie Wang, Xiaolong Hu, Kehui Ouyang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuting WeiJiangxi Province Key Laboratory of Animal Nutrition, Animal Nutrition and Feed Safety Innovation Team, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.ORCID 0009-0001-8615-7337
Yang ZhangJiangxi Province Key Laboratory of Animal Nutrition, Animal Nutrition and Feed Safety Innovation Team, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.
Xin LiuJiangxi Province Key Laboratory of Animal Nutrition, Animal Nutrition and Feed Safety Innovation Team, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.
Xinyu ChenJiangxi Province Key Laboratory of Animal Nutrition, Animal Nutrition and Feed Safety Innovation Team, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.
Guwei LuJiangxi Province Key Laboratory of Animal Nutrition, Animal Nutrition and Feed Safety Innovation Team, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.
Yijie WangJiangxi Province Key Laboratory of Animal Nutrition, Animal Nutrition and Feed Safety Innovation Team, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.
Xiaolong HuJiangxi Province Key Laboratory of Animal Nutrition, Animal Nutrition and Feed Safety Innovation Team, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.ORCID 0000-0001-9071-0177
Kehui OuyangJiangxi Province Key Laboratory of Animal Nutrition, Animal Nutrition and Feed Safety Innovation Team, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.

Funding

National Natural Science Foundation of China 32160807，32260861
6 · The paper itself

Abstract

Prolonged high temperature and humidity pose significant challenges to sheep health and productivity due to heat stress. This research assessed the physiological regulatory impact of supplementing heat-stressed Hu sheep with rumen-protected taurine. Forty-eight animals were assigned to four groups receiving different taurine doses over a 63-day period. A comprehensive evaluation was conducted on growth performance, nutrient digestibility, serum biochemical parameters, antioxidant and immune indices, transcriptomic profiles, and gut microbiota composition. Dietary supplementation with 0.4% RPT significantly enhanced feed intake, daily weight gain, and feed efficiency. Serum analysis revealed increased taurine and high-density lipoprotein levels, reduced cortisol and inflammatory cytokines, and elevated antioxidant enzyme activity. Transcriptomic analysis identified differentially expressed genes enriched in immune and antiviral pathways, including JAK-STAT signaling pathway being among those highlighted. Gut microbiota profiling showed increased diversity and improved composition, particularly

Indexed as

anti-inflammatorygut microbiotaheat stresssheeptaurine

Identifiers

PMID42193736
PMCPMC13203344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.