ArticleAntioxidants (Basel, Switzerland)2026
NFAT5: A Metabolic Time Capsule Encoding the History of Paternal Metabolic Oxidative Stress Within the Male Reproductive Tract.
Nicola Mosca, Antonella Migliaccio, Teresa Chioccarelli, Donato Cappetta, Antonella De Angelis, Marialucia Telesca, Liberato Berrino, Danila Valletta, Alice Luddi, Chiara Donati and 8 more
Abstract read
In one paragraphArticle in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
18 authors.
Nicola MoscaDepartment of Environmental, Biological, Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli", 81100 Caserta, Italy.ORCID 0000-0003-0405-3807 Antonella MigliaccioDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Teresa ChioccarelliDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-1720-1496 Donato CappettaDepartment of Experimental Medicine, University of Salento, 73100 Lecce, Italy.
Antonella De AngelisDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Marialucia TelescaDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Liberato BerrinoDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0009-0001-5173-363X Danila VallettaDepartment of Environmental, Biological, Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli", 81100 Caserta, Italy.ORCID 0009-0007-3984-3784 Alice LuddiDepartment of Molecular Medicine and Development, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-4946-7336 Chiara DonatiDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50100 Florence, Italy.ORCID 0000-0003-2224-4199 Paola PiomboniDepartment of Molecular Medicine and Development, University of Siena, 53100 Siena, Italy.ORCID 0000-0003-2987-7028 Charles CouttonHôpital Couple-Enfant, Centre Hospitalier Universitaire de Grenoble, UM de Génétique Chromosomique, 38000 Grenoble, France.ORCID 0000-0002-8873-8098 Guillaume MartinezHôpital Couple-Enfant, Centre Hospitalier Universitaire de Grenoble, UM de Génétique Chromosomique, 38000 Grenoble, France.ORCID 0000-0002-7572-9096 Gilda CobellisDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0001-5884-9208 Chiara SchiraldiDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-1066-843X Nicoletta PotenzaDepartment of Environmental, Biological, Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli", 81100 Caserta, Italy.ORCID 0000-0002-9736-792X Rosanna ChianeseDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0003-3631-1794 Francesco ManfrevolaDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Funding
Italian Ministry of Economic Development-MISE "InCube" No. F/200035/02/X45Italian Ministry of University and Research through the "Projects of great national interest" (PRIN) 2022 N° 20223H8LFM_001
6 · The paper itselfAbstract
Leydig cells (LCs) represent a somatic testicular population responsible for testosterone synthesis, a hormone essential for spermatogenesis and male fertility. The obesity condition impairs LC steroidogenic activity, contributing to testicular oxidative stress and male reproductive dysfunctions. Using a high-fat-diet (HFD) murine model, we investigated the regulatory role of the nuclear factor of activated T cells 5 (NFAT5s) in the obesity-induced LC damage and the resulting alterations in intergenerationally inherited sperm circRNA cargo. Our findings reveal a significant upregulation of both
Indexed as
circRNAsHFD-oxidative stressintergenerational inheritancemale infertilityNFAT5
Identifiers
PMID42193266
PMCPMC13203630
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390