N-Acetylcysteine Mitigates Renal Fibrosis by Modulating Inflammasome and Gluconeogenic Pathways Under Cardiometabolic Stress.

Ching-Chun Chen, Hui-Pei Huang, I-Ning Tsai, Huei-Jane Lee, Chau-Jong Wang

Abstract read

In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ching-Chun ChenInstitute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.

Hui-Pei HuangDepartment of Biochemistry, School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.

I-Ning TsaiInstitute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.ORCID 0009-0006-3508-2597

Huei-Jane LeeDepartment of Biochemistry, School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.ORCID 0000-0003-0792-1913

Chau-Jong WangDepartment of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.

Funding

National Science and Technology Council NSTC 114-2320-B-040-006

6 · The paper itself

Abstract

Cardio-renal metabolic (CRM) syndrome, characterized by insulin resistance and dyslipidemia, disrupts renal insulin signaling, enhances oxidative stress, and activates inflammasome pathways, ultimately promoting renal fibrosis and kidney dysfunction. Aberrant renal gluconeogenesis has emerged as a critical contributor to tubular injury under cardiometabolic stress; however, its mechanistic linkage to inflammatory and fibrotic remodeling remains incompletely defined. In this study, ApoE

Indexed as

cardiometabolic stressepithelial–mesenchymal transitioninflammasomeN-acetylcysteinerenal fibrosisrenal gluconeogenesis

Identifiers

PMID42193257

DOI10.3390/antiox15050636

PMCPMC13203279

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.