Evidence map›Paper›PMID 42193223›Full record

ArticleAntioxidants (Basel, Switzerland)2026

Anti-Inflammatory Activity of In Vitro Digested Manna in a Caco-2 and RAW264.7 Cells Co-Culture Model of Inflammatory Bowel Disease.

Ilenia Concetta Giardina, Mussa Makran, Ignazio Restivo, Francesco Pappalardo, Guadalupe Garcia-Llatas, Maria Cristina Barbalace, Luisa Tesoriere, Antonio Cilla, Alessandro Attanzio

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ilenia Concetta GiardinaDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Via Archirafi 28, 90123 Palermo, Italy.ORCID 0000-0001-9225-0434
Mussa MakranNutrition and Food Science Area, Faculty of Pharmacy and Food Sciences, University of Valencia, Av. Vicente Andrés Estellés s/n, 46100 Burjassot, Spain.ORCID 0000-0002-6522-6073
Ignazio RestivoDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Via Archirafi 28, 90123 Palermo, Italy.ORCID 0000-0003-1833-2356
Francesco PappalardoDepartment Analytics of R&D, Bionap s.r.l., C. da Fureria, Zona Industriale Ovest, Piano Tavola, 95032 Belpasso, Italy.ORCID 0000-0002-8569-8246
Guadalupe Garcia-LlatasNutrition and Food Science Area, Faculty of Pharmacy and Food Sciences, University of Valencia, Av. Vicente Andrés Estellés s/n, 46100 Burjassot, Spain.ORCID 0000-0002-4681-4208
Maria Cristina BarbalaceDepartment for Life Quality Studies, Alma Mater Studiorum, University of Bologna, Corso d'Augusto 237, 47921 Rimini, Italy.ORCID 0000-0001-5686-0470
Luisa TesoriereDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Via Archirafi 28, 90123 Palermo, Italy.ORCID 0000-0002-7980-7530
Antonio CillaNutrition and Food Science Area, Faculty of Pharmacy and Food Sciences, University of Valencia, Av. Vicente Andrés Estellés s/n, 46100 Burjassot, Spain.ORCID 0000-0001-6532-9032
Alessandro AttanzioDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Via Archirafi 28, 90123 Palermo, Italy.ORCID 0000-0002-6622-028X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) involves intestinal barrier dysfunction and chronic inflammation. Manna, derived from the solidified phloem sap of

Indexed as

anti-inflammatorybioaccessible fractionco-culture modelFraxinus sp.inflammatory bowel diseasemanna bioactivity

Identifiers

PMID42193223
PMCPMC13203731

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.