Combined Fish Oil and Pine Bark Extract Supplementation Improves Short-Term Memory and the Antioxidant Status in Middle-Aged and Older Adults with Mild Cognitive Impairment: A Randomized Double-Blind, Parallel-Group Pilot Study.

Tse-Chia Hsiao, Cheng-Dien Hsu, Qian Xiao, Yi-Hsiu Chen, Yannick Piriou, Hitoshi Shirakawa, Suh-Ching Yang

Abstract read

In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Tse-Chia HsiaoSchool of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan.

Cheng-Dien HsuDepartment of Psychiatry, Taiwan Adventist Hospital, Taipei 10556, Taiwan.

Qian XiaoSchool of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan.

Yi-Hsiu ChenSchool of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan.

Yannick PiriouQWB, Novapole, Zone de la Nau, 2 rue des Fresnes, 19240 Saint-Viance, France.ORCID 0000-0001-6464-1518

Hitoshi ShirakawaLaboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, Sendai 980-8857, Japan.ORCID 0000-0002-4828-5274

Suh-Ching YangSchool of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0002-1579-2165

Funding

Formosa Produce Corporation (New Taipei City, Taiwan) A-109-079

6 · The paper itself

Abstract

Mild cognitive impairment (MCI) represents an intermediate stage between normal cognitive function and dementia. Delaying the onset or progression of dementia has therefore become a key research priority. Although previous studies have examined the individual effects of fish oil or pine bark extract on cognitive decline, their findings remain inconclusive. In this study, we compared the effects of fish oil alone versus fish oil combined with pine bark extract on cognitive function and the oxidative status in patients with MCI. Participants aged 55-75 years with MCI were enrolled in a 24-week, double-blind, parallel-group trial, and they were randomly assigned to either a fish oil group (F group,

Indexed as

antioxidative statuscognitive functionfish oilmild cognitive impairmentpine bark extract

Identifiers

PMID42193210

DOI10.3390/antiox15050588

PMCPMC13203458

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.