Evidence map›Paper›PMID 42193191›Full record

ArticleAntioxidants (Basel, Switzerland)2026

Anticancer Effects of Broccoli Sprout Extract and Sulforaphane Through ROS-Induced MAPK Pathway in Breast Cancer Cells and Xenografts.

Seung-On Lee, Ji Eun Yu, Laxman Subedi, Susmita Phuyal, Arjun Dhwoj Bamjan, Goo Yoon, Sang Hoon Joo, Suk-Jung Oh, Jin Woo Park, Jung-Hyun Shim

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Seung-On LeeDepartment of Biomedicine, Health & Life Convergence Sciences, BK21 Four, College of Pharmacy, Mokpo National University, Muan 58554, Republic of Korea.
Ji Eun YuDepartment of Biomedicine, Health & Life Convergence Sciences, BK21 Four, College of Pharmacy, Mokpo National University, Muan 58554, Republic of Korea.ORCID 0000-0002-9382-6914
Laxman SubediDepartment of Biomedicine, Health & Life Convergence Sciences, BK21 Four, College of Pharmacy, Mokpo National University, Muan 58554, Republic of Korea.ORCID 0000-0003-0857-4458
Susmita PhuyalDepartment of Biomedicine, Health & Life Convergence Sciences, BK21 Four, College of Pharmacy, Mokpo National University, Muan 58554, Republic of Korea.ORCID 0009-0003-2436-6373
Arjun Dhwoj BamjanDepartment of Biomedicine, Health & Life Convergence Sciences, BK21 Four, College of Pharmacy, Mokpo National University, Muan 58554, Republic of Korea.ORCID 0009-0007-9576-0537
Goo YoonDepartment of Pharmacy, College of Pharmacy, Mokpo National University, Muan 58554, Republic of Korea.ORCID 0000-0001-7998-4708
Sang Hoon JooCollege of Pharmacy, Daegu Catholic University, Gyeongsan 38430, Republic of Korea.ORCID 0000-0001-8660-884X
Suk-Jung OhResearch & Development, Ecoworld Pharm Co., Ltd., Damyang 57304, Republic of Korea.
Jin Woo ParkDepartment of Biomedicine, Health & Life Convergence Sciences, BK21 Four, College of Pharmacy, Mokpo National University, Muan 58554, Republic of Korea.ORCID 0000-0002-0001-7043
Jung-Hyun ShimDepartment of Biomedicine, Health & Life Convergence Sciences, BK21 Four, College of Pharmacy, Mokpo National University, Muan 58554, Republic of Korea.ORCID 0000-0002-4062-4016

Funding

National Research Foundation of Korea RS-2022-NR070862National Research Foundation of Korea RS-2023-00279744National Research Foundation of Korea RS-2024-00336900Regional Innovation System & Education 2025-RISE-14-001
6 · The paper itself

Abstract

Breast cancer treatment remains challenging due to therapeutic resistance and the limited availability of effective molecular targets. We investigated the anticancer effects of sulforaphane (SFN) and broccoli sprout extract (BSE), an SFN-enriched phytochemical formulation, in MCF7 and MDA-MB-231 breast cancer cells. Cell viability, colony formation, and apoptotic responses were evaluated using standard

Indexed as

broccoli sprout extractMAPK signaling pathwayoral bioavailabilityreactive oxygen speciessulforaphane

Identifiers

PMID42193191
PMCPMC13203652

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.