ArticleAntioxidants (Basel, Switzerland)2026
Enhanced Recovery of Bioactive Compounds from
Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThis study proposes a cascade strategy for the comprehensive valorization of
methodsThe approach is based on a combination of optimized Ultrasound-assisted extraction (UAE) followed by High-pressure homogenization (HPH) of the residual biomass from both whole and ground leaves. UAE parameters (temperature, process duration, and ethanol concentration) were optimized to maximize the yield of total phenolic content (TPC), total flavonoid content (TFC), and antioxidant activity (DPPH, FRAP).
resultsThe optimal conditions (55.5 °C, 69.7 min, 40.8% ethanol) yielded extracts with a high TPC (289.55 mg GAE/g) and TFC (177.88 mg CE/g), reducing the processing time by 22% while increasing the TPC yield by 31% compared to the conventional solid-liquid extraction (SLE). It was found that primary extraction from whole leaves is more efficient than extraction from ground leaves, suggesting that the energy-intensive preliminary grinding step could be eliminated. The application of HPH to the residual biomass provided a significant secondary release of bioactive compounds, exceeding high-shear mixing (HSM) by up to 1.5 times for whole leaves. Kinetic analysis showed a higher release of bioactive compounds from whole leaves compared to ground leaves.
conclusionsThe proposed UAE + HPH cascade process is a sustainable approach, ensuring rational use of resources and a significant increase in the total yield of antioxidants from
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