ArticleAntioxidants (Basel, Switzerland)2026
Tacrolimus (FK506) Attenuates Hepatic Ischemia-Reperfusion Injury via Oxidative Glutathione Metabolism and Suppression of Lipoxygenase-Mediated Cell Death.
Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundHepatic ischemia-reperfusion injury (IRI) remains a major challenge in liver transplantation (LTx) and hepatectomy. Previous studies identified a 12/15-lipoxygenase (12/15-LOX)-driven lipid peroxidation cascade promoting cell death, whereas glutathione peroxidase 4 (GPx4)-dependent metabolism acts antagonistically. This study investigated whether tacrolimus protects against hepatic IRI through this redox axis.
methodsMale
resultsTacrolimus increased the oxidative glutathione activity quotient (GSSG/GSH) by 75.1% (
conclusionsTacrolimus preconditioning mitigates hepatic IRI through a glutathione-linked redox-signaling-cell death axis and exerts cytoprotective effects beyond immunosuppression.
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