Loss of Peroxiredoxin 6 Drives Age-Related Klf9/NF-

Bhavana Chhunchha, Eri Kubo, Deepali Lehri, Dhirendra P Singh

Abstract read

In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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5 · Who and what money

Authors and funding

4 authors.

Bhavana ChhunchhaDepartment of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0001-9613-8765

Eri KuboDepartment of Ophthalmology, University of Kanazawa, Kanazawa 9200293, Japan.ORCID 0000-0001-6789-9311

Deepali LehriDepartment of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Dhirendra P SinghDepartment of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0003-3311-2191

Funding

National Eye Institute, NIH EY36404Research to Prevent Blindness (RPB) NAUNMC NA

6 · The paper itself

Abstract

The abnormal activation of the Nlrp3 (Nod-like receptor pyrin 3) inflammasome, in response to oxidative stress or impaired antioxidant defense, is linked to aging-related diseases. Previously, we have shown that Peroxiredoxin (Prdx)6 deficiency triggers reactive oxygen species (ROS)-dependent activation of Kruppel-like factor (Klf)9/Nlrp3 inflammasome in aging lens epithelial cells (LECs). Herein, we test the therapeutic efficacy of Prdx6 delivery in abating the oxidative stress-induced aberrant activation of the Klf9/NF-

Indexed as

agingKlf9NF-κBNlrp3oxidative stressPrdx6

Identifiers

PMID42193155

DOI10.3390/antiox15050532

PMCPMC13203287

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.