Evidence map›Paper›PMID 42193095›Full record

ArticleCurrent issues in molecular biology2026

Cytotoxic and Antimelanoma Activity of Selected 3-Methyl-1,6-diazaphenothiazines in Human Melanoma Cells-In Vitro Studies.

Beata Morak-Młodawska, Małgorzata Jeleń, Zuzanna Rzepka, Milena Koch, Dorota Wrześniok

Abstract read
In one paragraph

Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Beata Morak-MłodawskaDepartment of Organic Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Jagiellońska 4, 41-200 Sosnowiec, Poland.ORCID 0000-0001-5389-1079
Małgorzata JeleńDepartment of Organic Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Jagiellońska 4, 41-200 Sosnowiec, Poland.ORCID 0000-0002-4144-990X
Zuzanna RzepkaDepartment of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Jagiellońska 4, 41-200 Sosnowiec, Poland.ORCID 0000-0001-7892-0462
Milena KochDepartment of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Jagiellońska 4, 41-200 Sosnowiec, Poland.
Dorota WrześniokDepartment of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Jagiellońska 4, 41-200 Sosnowiec, Poland.ORCID 0000-0002-6918-3330

Funding

Medical University of Silesia, Poland BNW-1-048/K/5/F and BNW-1-035/K/5/F and BNW-2-016/N/5/F
6 · The paper itself

Abstract

The cytotoxic and mechanistic effects of novel 10-substituted 3-methyl-1,6-diazaphenothiazines were investigated in human melanoma models. Antiproliferative activity was evaluated in vitro using the WST-1 assay in four melanoma cell lines (A375, C32, G361, and SK-MEL-28) and normal human dermal fibroblasts (HDF). Among the tested derivatives, compound

Indexed as

1,6-diazaphenothiazinescytotoxicityDNA damagemelanoma cellsmitochondrial potentialWST-1 assay

Identifiers

PMID42193095
PMCPMC13206610

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.