ArticleCurrent issues in molecular biology2026
Cellular Origins and Context-Dependent Prognostic Effects of Lactate Metabolism Genes Reveal Novel Molecular Subtypes in Gastric Cancer.
Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveGastric cancer (GC) exhibits profound heterogeneity, yet the contribution of lactate metabolism reprogramming to this diversity and its cellular basis remain incompletely understood. This study aimed to dissect GC heterogeneity through lactate metabolism-related genes (LMRGs), with a focus on the cellular origins and context-specific functions of key genes.
methodsWe performed consensus clustering of TCGA GC samples (
resultsWe identified two distinct GC subtypes: G1, a glycolytic and immunosuppressive subtype associated with poor prognosis, and G2, an immune-activated subtype with better prognosis. Crucially, single-cell analysis revealed that the hub gene
conclusionsThis study uncovers two distinct metabolic-immune subtypes of GC and demonstrates that the prognostic effect of
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