Evidence map›Paper›PMID 42193078›Full record

ArticleCurrent issues in molecular biology2026

mTOR Inhibition Drives Mutation-Specific Remodeling of Lysosomal and Autophagic Pathways and GCase Activity in PBMC-Derived Macrophages from Patients with GBA1-Associated Parkinson's Disease.

Anastasia Bezrukova, Katerina Basharova, Anton Emelyanov, Anna Lavrinova, Anna Krapova, Ekaterina Galkina, Ekaterina Skudarnova, Galina Baydakova, Irina Miliukhina, Ekaterina Zakharova and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anastasia BezrukovaPetersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Centre «Kurchatov Institute», 1, mkr. Orlova Roshcha, 188300 Gatchina, Russia.
Katerina BasharovaPetersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Centre «Kurchatov Institute», 1, mkr. Orlova Roshcha, 188300 Gatchina, Russia.ORCID 0000-0003-3078-3918
Anton EmelyanovPetersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Centre «Kurchatov Institute», 1, mkr. Orlova Roshcha, 188300 Gatchina, Russia.
Anna LavrinovaPetersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Centre «Kurchatov Institute», 1, mkr. Orlova Roshcha, 188300 Gatchina, Russia.ORCID 0009-0007-2824-5762
Anna KrapovaPetersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Centre «Kurchatov Institute», 1, mkr. Orlova Roshcha, 188300 Gatchina, Russia.
Ekaterina GalkinaPetersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Centre «Kurchatov Institute», 1, mkr. Orlova Roshcha, 188300 Gatchina, Russia.
Ekaterina SkudarnovaPetersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Centre «Kurchatov Institute», 1, mkr. Orlova Roshcha, 188300 Gatchina, Russia.
Galina BaydakovaResearch Center for Medical Genetics, Moskvorechie Str. 1, 140207 Moscow, Russia.
Irina MiliukhinaInstitute of Human Brain RAS, Akademika Pavlova Street, 12A, 197376 Saint Petersburg, Russia.
Ekaterina ZakharovaResearch Center for Medical Genetics, Moskvorechie Str. 1, 140207 Moscow, Russia.
Sofya PchelinaPetersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Centre «Kurchatov Institute», 1, mkr. Orlova Roshcha, 188300 Gatchina, Russia.
Tatiana UsenkoPetersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Centre «Kurchatov Institute», 1, mkr. Orlova Roshcha, 188300 Gatchina, Russia.ORCID 0000-0002-5132-2283

Funding

Russian Science Foundation 25-25-00920
6 · The paper itself

Abstract

To date, we and others have demonstrated that GBA1-associated Parkinson's disease (GBA1-PD) exhibits hyperactivation of mTOR and impairment of mTOR-regulated autophagy. Our previous study showed that the degree of autophagy impairment depends on the type of

Indexed as

autophagyGBA1GCase activitymacrophagesmTORParkinson’s diseaseTorin 1

Identifiers

PMID42193078
PMCPMC13204306

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.