Evidence map›Paper›PMID 42193054›Full record

ArticleCurrent issues in molecular biology2026

WWOX-Related Epileptic Encephalopathy (WOREE Syndrome): Clinical Case Study and Literature Review.

Annamaria Sapuppo, Roberta Rizzo, Gaia Fusto, Roberta Rocca, Vincenzo Sortino, Xena Giada Pappalardo, Martino Ruggieri, Raffaele Falsaperla

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Annamaria SapuppoUnit of Pediatrics and Pediatric Emergency Department, Azienda Ospedaliero-Universitaria Policlinico "Rodolico-San Marco", San Marco Hospital, 95123 Catania, Italy.ORCID 0000-0001-9433-026X
Roberta RizzoDepartment of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, 95123 Catania, Italy.
Gaia FustoDepartment of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, 95123 Catania, Italy.
Roberta RoccaPostgraduate Training Program in Pediatrics, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
Vincenzo SortinoUnit of Catania, Institute for Research and Biomedical Innovation (IRIB), National Council of Research, 95126 Catania, Italy.ORCID 0000-0002-0188-8430
Xena Giada PappalardoDepartment of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, 95123 Catania, Italy.
Martino RuggieriUnit of Clinical Pediatrics and Unit of Rare Disease AOU "Policlinico", PO "G. Rodolico", University of Catania, 95123 Catania, Italy.
Raffaele FalsaperlaDepartment of Medical Science-Pediatrics, University of Ferrara, 44124 Ferrara, Italy.ORCID 0000-0002-4482-3506

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The WW domain-containing oxidoreductase (

Indexed as

autosomal recessive spinocerebellar ataxia 12 (SCAR12infantile epileptic encephalopathy 28 (IEE28MIM: 614322)MIM: 616211)whole exome sequencing (WES)WW domain-containing oxidoreductase (WWOX) gene (MIM: 605131)WWOX-related epileptic encephalopathy (WOREE) syndrome

Identifiers

PMID42193054
PMCPMC13205014

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.