ArticleCurrent issues in molecular biology2026
Total Antioxidant Capacity and Total Oxidative Capacity in Multi-Modal Opioid-Based Therapy for Non-Cancer Pain: Analysis of Redox Status.
Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Current scientific reports on pain pharmacotherapy focus on the side effects of opioid medications related to dysregulation of the oxidative-antioxidant balance and immunomodulation. Initial observations concerned the use of opioids in the treatment of acute postoperative and cancer pain. Little is known about oxidative stress modulation in multi-modal opioid-based analgesia for chronic non-cancer pain. The aim of this study was to describe oxidative stress using plasma total antioxidant capacity (TAC) and total oxidative capacity (TOC), to assess whether these metrics are dependent on pain intensity and the scheme of analgesia. The study group consisted of patients with chronic low back pain, who were divided under the following treatments: multi-modal opioid-based therapy (n = 42), monotherapy with opioids (n = 28), and the control group (n = 11). A significantly lower TAC was observed in the study group compared to the monotherapy and control groups (220 µmol/L vs. 295 µmol/L,
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