Long-Term Oncologic Outcomes of Induction Chemotherapy Followed by Surgery Versus Upfront Surgery in Oral Cavity Squamous Cell Carcinoma.

Yu-Fu Su, Po-Chien Shen, Yi-Jan Hsia, Wen-Yen Huang, Jing-Min Hwang

Abstract read

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Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Yu-Fu SuDepartment of Radiation Oncology, Tri-Service General Hospital, National Defense Medical University, Taipei 114, Taiwan.ORCID 0009-0003-6704-5270

Po-Chien ShenDepartment of Radiation Oncology, Tri-Service General Hospital, National Defense Medical University, Taipei 114, Taiwan.

Yi-Jan HsiaMedical Department and Division of Oral Maxillofacial Surgery, Taipei Tzuchi Hospital, The Buddhist Tzuchi Medical Foundation, New Taipei City 231, Taiwan.

Wen-Yen HuangDepartment of Radiation Oncology, Tri-Service General Hospital, National Defense Medical University, Taipei 114, Taiwan.

Jing-Min HwangDepartment of Radiation Oncology, Taipei Tzuchi Hospital, The Buddhist Tzuchi Medical Foundation, New Taipei City 231, Taiwan.

Funding

Chi Mei Medical Center CMNDMC10912Ministry of Science and Technology MOST106-2314-B-016-006National Defense Medical College MND-MAB-D-115219Tri-Service General Hospital TSGH-C03-114039,C03-115039

6 · The paper itself

Abstract

backgroundThe optimal role of induction chemotherapy (IC) in the management of oral cavity squamous cell carcinoma (OCSCC) remains controversial. This study compared oncologic outcomes between IC followed by surgery and concurrent chemoradiotherapy (CCRT) and upfront surgery followed by adjuvant CCRT.

methodsWe retrospectively analyzed 98 patients with OCSCC treated between 2011 and 2017. Overall survival (OS), cancer-specific survival (CSS), and local control (LC) were evaluated using Kaplan-Meier survival analysis and Cox proportional hazards models to identify prognostic factors.

resultsFifty patients received IC and 48 underwent upfront surgery. With a median follow-up of 77.8 months, no significant differences in OS, CSS, or LC were observed between treatment groups (OS: HR 1.31,

conclusionsIC followed by surgery was associated with no statistically significant differences in oncologic outcomes compared with upfront surgery followed by adjuvant CCRT. Prognosis was primarily determined by pathological risk factors rather than treatment sequence.

Indexed as

induction chemotherapyoral cavity squamous cell carcinomaprognostic factorssurgerysurgical margins

Identifiers

PMID42192950

DOI10.3390/cancers18101590

PMCPMC13204267

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