Evidence map›Paper›PMID 42192931›Full record

ArticleCancers2026

The SLC25A45-TML Axis as a Biological Foundation for a Multivariable Plasma Metabolite Signature for High-Precision Prostate Cancer Detection.

Liang Zhao, Raghothama Chaerkady, Naseruddin Höti, Eric Zhao, Anirudh Kashyap, Morgan Fair, Qing Wang, Xiaonan Kang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Liang ZhaoComplete Omics Inc., Baltimore, MD 21227, USA.ORCID 0000-0002-2126-6778
Raghothama ChaerkadyComplete Omics Inc., Baltimore, MD 21227, USA.ORCID 0000-0002-8081-253X
Naseruddin HötiComplete Omics Inc., Baltimore, MD 21227, USA.
Eric ZhaoGilman School, Baltimore, MD 21210, USA.
Anirudh KashyapComplete Omics Inc., Baltimore, MD 21227, USA.
Morgan FairComplete Omics Inc., Baltimore, MD 21227, USA.
Qing WangComplete Omics Inc., Baltimore, MD 21227, USA.ORCID 0000-0002-7979-766X
Xiaonan KangRenji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.ORCID 0009-0007-5942-1204

Funding

Science and Technology Commission of Shanghai Municipality 24DZ2202900
6 · The paper itself

Abstract

backgroundProstate cancer remains a significant global health burden, yet current diagnostic reliance on PSA screening is heavily hampered by limited specificity and high rates of overdiagnosis.

methodsTo address this clinical bottleneck, we utilized a highly sensitive Complete360

resultsOur analysis identified 28 significantly altered metabolites (

conclusionsUltimately, this study provides a discovery-phase proof-of-concept for the SLC25A45-TML axis as a mechanistically grounded, stage-independent liquid biopsy, offering a rational, non-invasive framework to significantly improve PCa detection.

Indexed as

bipartite metabolic ratiosfatty acid oxidationmetabolomicspolyamine metabolismprostate cancer diagnosisSLC25A45-TML axis

Identifiers

PMID42192931
PMCPMC13204762

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.