ArticleCancers2026
Dynamic HALP Score as a Time-Dependent Prognostic Biomarker in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation.
Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
BACKGROUND AND
objectivesThe hemoglobin, albumin, lymphocyte, and platelet (HALP) score is an immunonutritional biomarker reflecting systemic inflammation, nutritional status, and immune competence. Its dynamic behavior and prognostic relevance in multiple myeloma (MM) following autologous stem cell transplantation (ASCT) remain insufficiently characterized. MATERIALS AND
methodsIn this retrospective cohort study, 95 MM patients undergoing ASCT were analyzed. HALP scores were calculated at diagnosis and at post-transplant day +100, and dynamic changes (ΔHALP) were assessed. Associations with overall survival (OS) and progression-free survival (PFS) were evaluated using Kaplan-Meier and multivariable Cox regression analyses, with maintenance therapy incorporated as a covariate.
resultsDuring a median follow-up of 50 months (range: 11.0-144.0), 36.8% of patients progressed or relapsed, and 23.2% died. Baseline HALP was associated with both OS and PFS in unadjusted analyses; however, the inverse association at diagnosis was substantially attenuated after adjustment for maintenance therapy (HR: 0.71, 95% CI: 0.28-1.80;
conclusionsPost-transplant HALP at day +100 emerged as the most robust HALP-based prognostic indicator for PFS. Given the small sample size, limited OS events (
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