Evidence map›Paper›PMID 42192913›Full record

ArticleCancers2026

Atovaquone Targets Mitochondrial Metabolism and Enhances Radiosensitivity of Diffuse Intrinsic Pontine Glioma.

Faiqa Mudassar, Kristina M Cook, Zachary N Warnken, Neha Bal, Joey Lai, Brian Gloss, Holly P McEwen, Ryan J Duchatel, Geraldine M O'Neill, Harriet Gee and 2 more

Abstract read
In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Faiqa MudassarTranslational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, NSW 2145, Australia.ORCID 0000-0001-7070-9590
Kristina M CookTranslational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, NSW 2145, Australia.ORCID 0000-0002-0503-7166
Zachary N WarnkenVia Therapeutics LLC, Austin, TX 78712-0126, USA.ORCID 0000-0002-1028-134X
Neha BalTranslational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, NSW 2145, Australia.
Joey LaiWestmead Research Hub Core Facilities, The Westmead Institute for Medical Research, Sydney, NSW 2145, Australia.
Brian GlossWestmead Research Hub Core Facilities, The Westmead Institute for Medical Research, Sydney, NSW 2145, Australia.
Holly P McEwenCancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW 2308, Australia.ORCID 0000-0002-8233-1553
Ryan J DuchatelCancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW 2308, Australia.ORCID 0000-0002-3651-7672
Geraldine M O'NeillFaculty of Medicine and Health, Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia.
Harriet GeeTranslational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, NSW 2145, Australia.ORCID 0000-0001-7397-8585
Han ShenTranslational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, NSW 2145, Australia.ORCID 0000-0003-2435-2150
Eric HauTranslational Radiation Biology and Oncology Laboratory, Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, NSW 2145, Australia.

Funding

Cancer Institute NSW Career Development FellowshipCure Brain Cancer FoundationNSW HealthSydney West Radiation Oncology NetworkThe Cure Starts NowThe DIPG CollaborativeThe Mark Hughes Foundation
6 · The paper itself

Abstract

Diffuse intrinsic pontine glioma (DIPG) is a lethal childhood brain tumor. Radiotherapy remains the standard of care, but tumors recur due to radioresistance. Tumor hypoxia contributes to radioresistance, and evidence of oxidative metabolism and hypoxia-associated transcriptomic programs suggests that hypoxia may be relevant in DIPG. We therefore investigated the FDA-approved mitochondrial inhibitor atovaquone as a strategy to target oxidative metabolism and enhance radiation response in DIPG.

Indexed as

diffuse intrinsic pontine gliomamitochondrial inhibitionoxygen consumption rateradiation

Identifiers

PMID42192913
PMCPMC13204253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.